Highly selective fluorescent sensor for homocysteine and cysteine
Highly selective fluorescent sensor for homocysteine and cysteine
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DOI：
10.1016/j.tetlet.2008.06.003
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发表时间：
2008-08-11
影响因子：
1.8
通讯作者：
Kim, Hae-Jo
中科院分区：
文献类型：
--
作者：
Kim, Tae-Ki;Lee, Dong-Nam;Kim, Hae-Jo
合成了一种基于香豆素的新型荧光传感器（1），用于选择性检测同型半胱氨酸（Hcy）和半胱氨酸（Cys）。该化学传感器通过噻嗪烷或噻唑烷的环形成对Hcy或Cys的选择性响应超过其他各种氨基酸。当加入Hcy或Cys时，1的荧光强度通过光诱导电子转移完全猝灭，灵敏度为亚毫摩尔浓度。(C)2008爱思唯尔有限公司保留所有权利。
A new fluorescent sensor (1) based on a coumarin was synthesized for the selective detection of homocysteine (Hcy) and cysteine (Cys). The chemosensor has shown a selective response to Hcy or Cys over other various amino acids via a ring formation of thiazinane or thiazolidine. When Hcy or Cys was added, the fluorescent intensity of 1 was completely quenched through a photo-induced electron transfer with the sensitivity of sub-millimolar concentration. (C) 2008 Elsevier Ltd. All rights reserved.