Flow-controlled expiration: a novel ventilation mode to attenuate experimental porcine lung injury
Flow-controlled expiration: a novel ventilation mode to attenuate experimental porcine lung injury
复制标题
DOI：
10.1093/bja/aeu058
复制
发表时间：
2014-09-01
影响因子：
9.8
通讯作者：
Schumann, S.
中科院分区：
文献类型：
--
作者：
Goebel, U.;Haberstroh, J.;Schumann, S.
背景尽管各种吸气呼吸调节在肺损伤中的作用已被广泛研究，但呼气呼吸调节的作用却鲜为人知。我们假设新开发的流量控制呼气（FLEX）模式提供了一种减轻实验性肺损伤的方法。在15只麻醉机械通气的猪上，静脉注射油酸诱发实验性急性呼吸窘迫综合征。肺损伤后（Pa-O2/FIO 2比值
Background. Whereas the effects of various inspiratory ventilatory modifications in lung injury have extensively been studied, those of expiratory ventilatory modifications are less well known. We hypothesized that the newly developed flow-controlled expiration (FLEX) mode provides a means of attenuating experimental lung injury.Methods. Experimental acute respiratory distress syndrome was induced by i.v. injection of oleic acid in 15 anaesthetized and mechanically ventilated pigs. After established lung injury (Pa-O2/FIO2 ratio