Histopathological parameters of recurrence and malignant transformation in sinonasal inverted papilloma
Histopathological parameters of recurrence and malignant transformation in sinonasal inverted papilloma
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DOI：
10.1080/00016480500312554
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发表时间：
2006-02-01
影响因子：
1.4
通讯作者：
Tsukuda, M
中科院分区：
文献类型：
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作者：
Katori, H;Nozawa, A;Tsukuda, M
结论.一个参数的组合可能是有用的预测鳞状细胞癌的临床过程中的内翻性乳头状瘤（IP）。特别是，参数角化过度，鳞状上皮增生和高有丝分裂指数是阴性预后指标。Objective.确定可预测IP中鳞状细胞癌复发和发展的组织病理学参数。材料和方法。我们使用以下参数分析了39例IP的组织病理学特征：肿瘤起源部位;骨侵犯的存在;炎性息肉的存在;内生与外生病变的比例;肿瘤上皮与间质的比例;角化过度的存在;鳞状上皮增生的存在;有丝分裂指数;粘蛋白球的数量;嗜酸性粒细胞的数量。结果骨转移与骨侵犯有关（p = 0.039），无炎性息肉（p = 0.033），肿瘤上皮细胞：基质（p = 0.037），角化过度增加（p = 0.030）、鳞状上皮增生（p = 0.044）、有丝分裂指数增加（p = 0.029）和嗜酸性粒细胞数量减少（p = 0.037）。多发性复发（无恶性肿瘤）与额窦起源（p = 0.042）、角化过度增加（p = 0.041）、鳞状上皮增生（p = 0.044）和有丝分裂指数增加（p = 0.031）相关。临床良性行为与炎性息肉的存在（p = 0.010）和角化过度的缺乏（p = 0.008）有关。
Conclusions. A combination of parameters may be useful in predicting the clinical course of squamous cell carcinoma in inverted papilloma (IP). In particular, the parameters hyperkeratosis, squamous epithelial hyperplasia and high mitotic index were negative prognostic indicators. Objective. To define histopathological parameters which could predict the recurrence and development of squamous cell carcinoma in IP. Material and methods. We analyzed the histopathological characteristics of 39 cases of IP using the following parameters: site of origin of tumor; presence of bone invasion; presence of inflammatory polyp; ratio of endophytic to exophytic lesions; ratio of neoplastic epithelium to stroma; presence of hyperkeratosis; presence of squamous epithelial hyperplasia; mitotic index; number of mucin globules; and number of eosinophils. Results. Malignancy was related to the presence of bone invasion ( p = 0.039), the absence of inflammatory polyp ( p = 0.033), increase in the ratio neoplastic epithelium: stroma ( p = 0.037), increase in hyperkeratosis ( p = 0.030), the presence of squamous epithelial hyperplasia ( p = 0.044), increase in the mitotic index ( p = 0.029) and a decrease in the number of eosinophils ( p = 0.037). Multiple recurrences ( without malignancy) were related to frontal sinus origin ( p = 0.042), increase in hyperkeratosis ( p = 0.041), the presence of squamous epithelial hyperplasia ( p = 0.044) and increase in the mitotic index ( p = 0.031). Clinically benign behavior was related to the presence of inflammatory polyp ( p = 0.010) and the absence of hyperkeratosis ( p = 0.008).