THE CHARACTERIZATION AND ENERGETIC POTENTIAL OF BROWN ADIPOSE-TISSUE IN MAN
THE CHARACTERIZATION AND ENERGETIC POTENTIAL OF BROWN ADIPOSE-TISSUE IN MAN
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DOI：
10.1042/cs0690343
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发表时间：
1985-01-01
期刊：
影响因子：
6
通讯作者：
RIAL, E
中科院分区：
文献类型：
--
作者：
CUNNINGHAM, S;LESLIE, P;RIAL, E
在成年男性中，通过目视检查、EM和与组织特异性解偶联蛋白结合的核苷酸在肾周脂肪库中检测到棕色脂肪。32 kdalton解偶联蛋白是功能活性的，显示出对质子的核苷酸敏感的电导和对脂肪酸的解偶联反应。人线粒体中解偶联蛋白的量相当于部分冷适应的豚鼠中的解偶联蛋白的量，表明具有一定的产热潜力。呼吸能力测量表明，成年男性的肾周脂肪总量仅占全身对输注去甲肾上腺素[去甲肾上腺素]反应的1/500。尽管棕色脂肪在动物研究中的数量上很重要，但在将其意义外推到成年人身上时必须相当谨慎。
In the adult man, brown fat is detected in perinephric fat depots by visual inspection, EM and nucleotide binding to the tissue-specific uncoupling protein. The 32 kdalton uncoupling protein is functionally active, showing a nucleotide-sensitive conductance to protons and uncoupling response to fatty acids. The amount of uncoupling protein in human mitochondria is equivalent to that in a partially cold-adapted guinea pig, indicating some potential for thermogenesis. Respiratory capacity measurements indicate that the total perinephric fat in adult man can only account for 1/500 of the whole-body response to infused noradrenaline [norepinephrine]. Although brown fat was quantitatively important in animal studies, considerable caution must be exercised in extrapolating its significance to adult man.