A NETWORK MODEL OF RESPIRATORY RHYTHMOGENESIS
A NETWORK MODEL OF RESPIRATORY RHYTHMOGENESIS
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DOI：
10.1152/ajpregu.1992.263.4.r962
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发表时间：
1992-10-01
影响因子：
--
通讯作者：
PACK, AI
中科院分区：
文献类型：
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作者：
OGILVIE, MD;GOTTSCHALK, A;PACK, AI
由Richter等人提出的三相呼吸网络的数学模型（News Physiol. Sci. 1：109-112，1986），并对其性质进行了研究。该模型再现了实验确定的五种生理上不同类型的神经元的膜电位的轨迹。逐步参数变化可产生仅具有两个单独电生理阶段的呼吸节律，导致呼吸暂停，或产生更复杂的放电模式。该模型的相位重置行为与扰动刺激，并与实验确定的相位重置数据。模型预测和实验结果之间有合理的协议。在该模型中，相位奇异性的属性使得通过适当定时的扰动来终止呼吸节律几乎是不可能的，这与实验观察一致。节律可以通过模拟来自上级喉神经的输入效应的改变而停止;节律被锁定在吸气后阶段。我们的结论是，我们的研究结果是一致的概念的网络振荡器的源的呼吸节律。
A mathematical model of the three-phase respiratory network proposed by Richter et al. (News Physiol. Sci. 1: 109-112, 1986) is developed and its properties are examined. The model reproduces the experimentally determined trajectories of membrane potential for the five physiologically distinct types of neurons included. Stepwise parameter changes can produce a respiratory rhythm with only two separate electrophysiological phases, result in apnea, or produce more complex patterns of firing. The phase-resetting behavior of the model was obtained with perturbing stimuli and is comparable to experimentally determined phase-resetting data. There is reasonable agreement between model predictions and experimental results. In the model, the properties of the phase singularity make termination of the respiratory rhythm by an appropriately timed perturbation virtually impossible, which is in agreement with experimental observations. The rhythm can be stopped by alterations that simulate the effect of input from the superior laryngeal nerve; the rhythm is locked in the postinspiratory phase. We conclude that our results are consistent with the concept of a network oscillator as the source of the respiratory rhythm.