Differential recovery of dopamine synthetic enzymes following MPTP and the consequences of GM1 ganglioside treatment.
Differential recovery of dopamine synthetic enzymes following MPTP and the consequences of GM1 ganglioside treatment.
复制标题
MPTP 后多巴胺合成酶的不同恢复以及 GM1 神经节苷脂治疗的后果。
DOI：
10.1016/0014-2999(90)90255-5
复制
发表时间：
1990
影响因子：
5
通讯作者：
Neff,NH
中科院分区：
文献类型：
--
作者：
Hadjiconstantinou,M;Neff,NH
After 7 days of treatment with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), 30 mg/kg i.p., tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) activities are decreased by more than 50% in the mouse striatum. Within 30 days, AAAD activity returns while TH activity remains depressed. TH activity can be restored to near normal by chronic treatment with GM1 ganglioside, 30 mg/kg i.p.
