The Influence of Education and Apolipoprotein ε4 on Mortality in Community-Dwelling Elderly Men and Women
The Influence of Education and Apolipoprotein ε4 on Mortality in Community-Dwelling Elderly Men and Women
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DOI：
10.1155/2018/6037058
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发表时间：
2018-01-01
影响因子：
4.7
通讯作者：
Baumgartner, Richard N.
中科院分区：
文献类型：
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作者：
Appiah, Duke;Baumgartner, Richard N.
我们调查了与载脂蛋白ε 4等位基因相关的死亡风险，并评估了载脂蛋白ε 4等位基因如何与504名老年人（平均年龄73岁，65.3%为女性）的教育相互作用，这些老年人于1993年参加了新墨西哥州衰老过程研究。在9年的随访中，在校正了年龄、社会人口学变量、医疗条件、肥胖和生活方式因素的模型中，与载脂蛋白<$3携带者相比，载脂蛋白<$3 2似乎与全因死亡率的较低风险相关（风险比（HR）=0.73，95%置信区间（CI）：0.30-1.71）。载脂蛋白ε 4等位基因使死亡风险增加近3倍（HR.2.76，CI：1.42-5.37）。教育和载脂蛋白<$4之间存在相互作用（p=0.027），与非携带者相比，104携带者的死亡率HR为1.59（0.64-3.96），其中大学教育>=大学教育的人; 6.66（1.90-23.4），其中大学教育或职业的人; 14.1（3.03-65.6），
We investigated the risk of death in relation to the apolipoprotein epsilon 4 allele and evaluated how it interacts with education in 504 elderly adults (mean age 73 years, 65.3% women) who were enrolled in 1993 into the New Mexico Aging Process Study. During 9 years of follow-up, apolipoprotein epsilon 2 appeared to be associated with a lower risk for all-cause mortality (hazard ratio (HR)=0.73, 95% confidence interval (CI): 0.30-1.71) compared to apolipoprotein epsilon 3 carriers in models adjusted for age, sociodemographic variables, medical conditions, adiposity, and lifestyle factors. The apolipoprotein epsilon 4 allele conferred almost a threefold elevated risk of mortality (HR. 2.76, CI: 1.42-5.37). An interaction between education and apolipoprotein epsilon 4 (p=0.027) was observed with the HR of mortality among epsilon 4 carriers compared to noncarriers being 1.59 (0.64-3.96) for those with >= college education; 6.66 (1.90-23.4) for those with some college or trade; and 14.1 (3.03-65.6) for participants with