Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
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DOI：
10.1016/s0145-305x(97)00027-x
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发表时间：
1997-11-01
影响因子：
2.9
通讯作者：
Effros, RB
中科院分区：
文献类型：
--
作者：
Effros, RB
The CD28 molecule, a disulfide-linked homodimer expressed on peripheral T cells and thymocytes, mediates an essential costimulatory signal following engagement of the T cell receptor (TCR). Increased proportions of CD28 - T cells have been observed during aging and in situations of chronic immune stimulation, but the origin and functional characteristics of these cells have been unclear. T cells which reach replicative senescence in culture after multiple rounds of cell division have shortened telomeres, respond poorly to stress stimuli, and no longer express CD28, suggesting that CD28 - T cells observed in vivo may be the progeny of memory cells which have been repeatedly stimulated. This review describes the features of T cell replicative senescence, presents several possible mechanisms for the generation of senescent T cells in vivo, and proposes that replicative senescence may explain immune exhaustion. (C) 1997 Elsevier Science Ltd. All rights reserved.
