RESTING-STATE FUNCTIONAL CONNECTIVITY DENSITY MAPPING OF ETIOLOGY CONFIRMED UNILATERAL PULSATILE TINNITUS PATIENTS: ALTERED FUNCTIONAL HUBS IN THE EARLY STAGE OF DISEASE
RESTING-STATE FUNCTIONAL CONNECTIVITY DENSITY MAPPING OF ETIOLOGY CONFIRMED UNILATERAL PULSATILE TINNITUS PATIENTS: ALTERED FUNCTIONAL HUBS IN THE EARLY STAGE OF DISEASE
复制标题
已证实病因的单侧搏动性耳鸣患者的静息态功能连接密度图：疾病早期功能中枢的改变
DOI：
10.1016/j.neuroscience.2015.09.032
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发表时间：
2015-12-03
期刊：
影响因子：
3.3
通讯作者：
Zhenchang, W.
中科院分区：
文献类型：
--
作者：
Han, L.;Pengfei, Z.;Zhenchang, W.
功能磁共振成像（fMRI）已被广泛用于识别耳鸣患者的内在局部神经活动和全球网络的改变。在这项研究中，功能连接密度（FCD）映射，一个新开发的voxelwise数据驱动的方法的基础上，功能磁共振成像，第一次被应用到测量的功能重组模式在32单侧搏动性耳鸣（PT）患者在疾病的早期阶段（小于48个月）。FCD分析用于计算短程和长程FCD值。还进行了与临床变量的相关性分析。与正常对照组相比，PT患者的短程FCD主要在楔前叶（PCu）、双侧额下回（IFG）和枕中回（MOG），长程FCD主要在PCu、扣带回后部（PCC）和双侧额中回（MFG）。此外，相关分析显示PT持续时间与右侧MOG的短程FCD值呈正相关。PCC的病程与长程FCD值之间也存在正相关关系。双侧背侧视区短/长程FCD的增加表明听觉皮层和双侧背侧视区之间的增强通路可能激活了“听觉枕叶激活”（AOAs）通路。双侧背侧视区FCD值的改变反映了不同脑区的合作。本研究为PT患者的连接性研究奠定了基础。我们的工作可能会促进对PT患者神经网络破坏的理解。(C)2015年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Functional magnetic resonance imaging (fMRI) has been widely used to identify altered intrinsic local neural activities and global networks of tinnitus patients. In this study, functional connectivity density (FCD) mapping, a newly developed voxelwise data-driven method based on fMRI, was applied for the first time to measure the functional reorganization pattern in thirty-two unilateral pulsatile tinnitus (PT) patients in the early stage of disease (less than 48 months). FCD analysis was employed to compute short-range and long-range FCD values. A correlation analysis with clinical variables was also performed. Compared with normal controls, PT patients showed significantly increased short-range FCD, mainly in the precuneus (PCu), bilateral inferior frontal gyrus (IFG) and middle occipital gyrus (MOG), and increased long-range FCD in the PCu, posterior cingulate cortex (PCC), and bilateral middle frontal gyrus (MFG). In addition, correlation analysis showed positive correlations between PT duration and short-range FCD values in the right MOG. Positive correlations were also found between the disease duration and the long-range FCD value in the PCC. The increased short-/long-range FCD in bilateral dorsal visual areas indicated that the enhanced pathway between the auditory cortex and bilateral dorsal visual areas may have activated the "auditory occipital activations" (AOAs) pathway. The bilaterally altered FCD values in the dorsal visual areas reflected the cooperation of different brain areas. This study is a foundation of the connectivity research in PT patients. Our work may advance the understanding of the disrupted neural network of patients with PT. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.