Longitudinal Changes in Placental Magnetic Resonance Imaging Relaxation Parameter in Murine Pregnancy: Compartmental Analysis.
Longitudinal Changes in Placental Magnetic Resonance Imaging Relaxation Parameter in Murine Pregnancy: Compartmental Analysis.
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DOI：
10.1159/000431223
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发表时间：
2016
影响因子：
2.1
通讯作者：
Neelavalli J
中科院分区：
文献类型：
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作者：
Krishnamurthy U;Szalai G;Shen Y;Xu Z;Yadav BK;Tarca AL;Chaiworapongsa T;Hernandez-Andrade E;Than NG;Haacke EM;Romero R;Neelavalli J
量化小鼠胎盘主要组成区域磁共振横向弛豫参数（T2）的妊娠依赖性纵向变化，并评估其对整体胎盘T2变化的相对贡献。定时妊娠CD-1小鼠在妊娠第13、15和17天（GD）在7.0特斯拉场强下进行磁共振成像（MRI）。定量胎盘及其组成的高血流灌注区和低血流灌注区的T2。使用线性混合效应模型拟合整个妊娠期的T2，并检验系数的显著性。在整个妊娠期间观察到胎盘及其组成区域的T2值降低。胎盘T2的时间变化估计为-1.85 msec/GD（p<0.0001），高灌注区为-1.00 msec/GD（p<0.001），低灌注区为-1.66 msec/GD（p<0.0001）。小鼠胎盘组成区的T2随着妊娠的进行而降低。虽然低灌注区的T2小于高灌注区，但它们的下降率相对于整个胎盘的下降率没有差异（p=0.24）。结果表明，在影响整体妊娠依赖性胎盘T2降低小鼠的组成体积分数的作用增加。
To quantify gestation-dependent longitudinal changes in the magnetic resonance transverse relaxation parameter (T2) of the major constituent regions of the mouse placenta and evaluate their relative contributions to changes in overall placental T2. Timed-pregnant CD-1 mice underwent magnetic resonance imaging (MRI) at 7.0 Tesla field strength, on gestational days (GD) 13, 15 and 17. T2 of placenta and its constituent high blood perfusion and low blood perfusion regions were quantified. A linear mixed-effects model was used to fit the T2 across gestation, and significance of coefficients was tested. A decrease in the T2 values of the placenta and its constituent regions was observed across gestation. Temporal change in T2 was estimated to be -1.85 msec/GD (p<0.0001) for the placenta, -1.00 msec/GD (p<0.001) for the high, and -1.66 msec/GD (p<0.0001) for the low perfusion zones. T2 of the constituent zones of the murine placenta decreases with advancing gestation. While the T2 of the low perfusion zone is smaller than the high perfusion zone, there is no difference in their decrease rate relative to that of the whole placenta (p=0.24). The results suggest increased role of constituent volume fractions in affecting overall gestation-dependent placental T2 decrease in mice.