A MEMS fabricated flexible electrode array for recording surface field potentials
A MEMS fabricated flexible electrode array for recording surface field potentials
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DOI：
10.1016/j.jneumeth.2005.10.016
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发表时间：
2006-05-15
影响因子：
3
通讯作者：
Rector, David M.
中科院分区：
文献类型：
--
作者：
Hollenberg, Brian A.;Richards, Cecilia D.;Rector, David M.
我们开发了一种在薄的聚酰亚胺（Kapton）基底上微制造柔性电极阵列的方法，该阵列经设计可在插入硬脑膜和颅骨之间获取表面脑电图记录时将创伤降至最低。该阵列由64个金电极组成，在间距为750μm的8×8网格上，每个电极直径为150μm。利用光刻工艺，可以实现电极的任意排列。我们使用该电极阵列记录诱发反应信号，以绘制皮质表面触须桶状区域的地形图，在8小时内信号稳定性极佳。用于这种制造的材料可能具有生物惰性，并且通过对设计进行一些额外修改，可以长期植入且副作用极小。视网膜假体、人体神经外科手术和神经学研究在一定程度上都受到所使用植入物的分辨率和生物相容性的限制。这种类型的阵列可以极大地提高可植入表面电极阵列的空间分辨率、信号质量和稳定性。（c）2005爱思唯尔有限公司。保留所有权利。
We developed a method to microfabricate flexible electrode arrays on a thin Kapton substrate, which was engineered to minimize trauma when inserted between the dura and skull to obtain surface EEG recordings. The array consisted of 64 gold electrodes, each 150 mu m in diameter on a 750 mu m spaced 8 x 8 grid. Using photolithographic procedures, any arrangement of electrodes can be implemented. We used the electrode array to record evoked response signals to create topographical maps of the whisker barrels on the cortical surface with excellent signal stability over a period of 8 h. The materials used for this fabrication are potentially biologically inert and, with some additional modifications to the design, can be chronically implanted with minimal side effects. Retinal prosthesis, human neurosurgery, and neurological research are all limited to some degree by the resolution and biological compatibility of the implants used. This type of array could greatly enhance the spatial resolution, signal quality, and stability of implantable surface electrode arrays. (c) 2005 Elsevier B.V. All rights reserved.