Distribution of spatial and nonspatial information in dorsal hippocampus
Distribution of spatial and nonspatial information in dorsal hippocampus
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DOI：
10.1038/45154
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发表时间：
1999-12-09
期刊：
影响因子：
64.8
通讯作者：
Deadwyler, SA
中科院分区：
文献类型：
--
作者：
Hampson, RE;Simeral, JD;Deadwyler, SA
哺乳动物大脑中的海马体是编码当前和保留过去经验所必需的，以前的研究表明，海马体中含有编码执行空间和非空间短期记忆任务所需信息的神经元。对海马体功能解剖的更详细的了解将为了解这种编码是如何发生的提供重要的见解。本研究表明，大鼠海马神经元在解剖学上沿海马的长度以不同的节段分布。每个纵段包含神经元簇，当动物执行具有空间属性的任务时，这些神经元簇就会变得活跃。在这些相同的片段中，有序排列的神经元对任务的非空间方面进行编码，以适应这些空间特征。因此，空间信息的解剖分离，以及非空间信息的交错表示，代表了一个结构框架，可能有助于解决海马体功能的相互矛盾的观点。
The hippocampus in the mammalian brain is required for the encoding of current and the retention of past experience, Previous studies have shown that the hippocampus contains neurons that encode information required to perform spatial and nonspatial short-term memory tasks. A more detailed understanding of the functional anatomy of the hippocampus would provide important insight into how such encoding occurs. Here we show that hippocampal neurons in the rat are distributed anatomically in distinct segments along the length of the hippocampus. Each longitudinal segment contains clusters of neurons that become active when the animal performs a task with spatial attributes. Within these same segments are ordered arrangements of neurons that encode the nonspatial aspects of the task appropriate to those spatial features. Thus, anatomical segregation of spatial information, together with the interleaved representation of nonspatial information, represents a structural framework that may help to resolve conflicting views of hippocampal function.