MELANOCYTE COLONIZATION AND PIGMENTATION OF BREAST CARCINOMA
MELANOCYTE COLONIZATION AND PIGMENTATION OF BREAST CARCINOMA
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DOI：
10.1111/j.1365-2559.1977.tb01641.x
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发表时间：
1977-01-01
期刊：
影响因子：
6.4
通讯作者：
EUSEBI, V
中科院分区：
文献类型：
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作者：
AZZOPARDI, JG;EUSEBI, V
在大多数[人]乳腺癌病例中，黑色素细胞对乳腺癌的定植伴随着黑色素对癌细胞的色素沉着，其中肿瘤细胞到达真皮-表皮界面。有证据表明，乳腺癌可能会以牺牲表皮为代价而定植，而表皮局部黑色素细胞已被耗尽。黑素细胞存在于淋巴管内的肿瘤细胞群中。乳腺癌的定植和色素沉着通常只能通过选择性染色方法才能轻松检测到。在极少数情况下，它可能很严重，并且在常规污渍中很容易被发现。从黑素细胞的生物学角度讨论了这种迁移现象的影响。
Colonization of mammary cancers by melanocytes with attendant pigmentation of cancer cells by melanin occurs in most cases of [human] breast cancer in which the dermal-epidermal interface is reached by the tumor cells. There is evidence to suggest that the mammary cancer may become colonized at the expense of the epidermis, which is focally depleted of melanocytes. Melanocytes can be found in groups of tumor cells within lymphatics. Colonization and pigmentation of breast cancer is usually only easily detected by selective staining methods. In rare cases it can be gross and easily detectable in routine stains. The implications of this migratory phenomenon are discussed in terms of the biology of the melanocyte.