Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian Hormone.
Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian Hormone.
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血清抗苗勒管激素表明慢性盆腔炎症会导致卵巢储备功能下降
DOI：
10.1371/journal.pone.0156130
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Chen ZJ
中科院分区：
文献类型：
--
作者：
Cui L;Sheng Y;Sun M;Hu J;Qin Y;Chen ZJ
探讨慢性盆腔炎对卵巢储备功能的潜在损害。病例对照研究。共招募了122名经子宫输卵管造影（HSG）诊断为双侧输卵管阻塞的妇女和217名正常输卵管的妇女。检测血清抗苗勒管激素（AMH）、基础卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）、睾酮（T），并记录窦卵泡计数（AFC）。双侧输卵管阻塞组AMH水平显著低于对照组[2.62（2.95）ng/ml vs. 3.37（3.11）ng/ml，P = 0.03]，调整BMI后差异仍存在（P调整= 0.04）。而FSH水平无统计学差异[7.00（2.16）IU/L vs. 6.74（2.30）IU/L]，LH [4.18（1.52）IU/L vs. 4.63（2.52）IU/L]，E2 [35.95（20.40）pg/ml vs. 34.90（17.85）pg/ml]、T [25.07±11.46 ng/dl vs. 24.84±12.75 ng/dl]和AFC [6.00（4.00）vs. 7.00（4.00）]在两组之间（p>0.05）。双侧输卵管阻塞患者AMH水平降低，提示慢性盆腔炎可能降低卵巢储备功能。在评估PID对女性生育能力的损害时应更加谨慎。
To explore the potential damaging effect of chronic pelvic inflammation on ovarian reserve. Case-control study. A total of 122 women with bilateral tubal occlusion, diagnosed by hysterosalipingography (HSG) and 217 women with normal fallopians were recruited. Serum anti-Mullerian hormone (AMH), basic follicle-stimulating hormone (FSH), luteining hormone (LH), estradiol (E2), and testosterone (T) were measured; and antral follicle counts (AFCs) were recorded. Significantly lower level of AMH was observed in women with bilateral tubal occlusion compared to control group [2.62 (2.95) ng/ml vs. 3.37 (3.11) ng/ml, P = 0.03], and the difference remained after adjustment of BMI (Padjust = 0.04). However, no statistical difference was found in the levels of FSH [7.00 (2.16) IU/L vs. 6.74 (2.30) IU/L], LH [4.18 (1.52) IU/L vs. 4.63 (2.52) IU/L], E2 [35.95 (20.40) pg/ml vs. 34.90 (17.85) pg/ml], T [25.07±11.46 ng/dl vs. 24.84±12.75 ng/dl], and AFC [6.00 (4.00) vs. 7.00 (4.00)] between two groups (p>0.05). Women with bilateral tubal occlusion showed decreased AMH level, suggesting that chronic pelvic inflammation may diminish ovarian reserve. More caution should be paid when evaluating the detriment of PID on female fertility.