Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum
Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum
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DOI：
10.2478/v10007-011-0030-6
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发表时间：
2011-09-01
影响因子：
2.8
通讯作者：
Janardhanan, Kainoor Krishnankutty
中科院分区：
文献类型：
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作者：
Joseph, Soniamol;Sabulal, Baby;Janardhanan, Kainoor Krishnankutty
本研究从灵芝中提取多糖，并利用体内模型研究其抗肿瘤和抗炎活性。G.灵芝多糖（GLP）抗埃利希细胞实体瘤的研究当在肿瘤植入后24小时给药时，100 mg kg（-1）体重的GLP显示肿瘤体积和肿瘤质量分别减少80.8%和77.6%。同样，相同剂量的GLP在肿瘤接种前给药时，肿瘤体积和肿瘤质量的抑制率分别为79.5%和81.2%。GLP在角叉菜胶诱导的（急性）和福尔马林诱导的（慢性）炎症试验中显示出显著的剂量依赖性活性。在100 mg kg（-1）剂量下，GLP在角叉菜胶诱导和福尔马林诱导试验中分别表现出57.6%和58.2%的抑制作用。
In this study, polysaccharides were isolated from Ganoderma lucidum (Polyporaceae) and their antitumor and anti-inflammatory activities were investigated using in vivo models. Potential antitumor activity was shown by G. lucidum polysaccharides (GLP) against solid tumor induced by Ehrlich's ascites carcinoma cells. GLP at 100 mg kg(-1) body mass showed 80.8 and 77.6% reduction in tumour volume and tumour mass, respectively, when administered 24 h after tumour implantation. Again, GLP at the same dose but when administered prior to tumour inoculation, showed 79.5 and 81.2% inhibition of tumour volume and tumour mass, respectively. GLP showed significant dose-dependent activity in carrageenean-induced (acute) and formalin-induced (chronic) inflammation assays. At 100 mg kg(-1), GLP exhibited 57.6 and 58.2% inhibition in carrageenean-induced and formalin-induced assays, respectively.