Temporal expression of an H2-linked locus in host response to mouse malaria
Temporal expression of an H2-linked locus in host response to mouse malaria
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DOI：
10.1007/s002510050603
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发表时间：
1999-12-01
期刊：
影响因子：
3.2
通讯作者：
Foote, SJ
中科院分区：
文献类型：
--
作者：
Burt, RA;Baldwin, TM;Foote, SJ
宿主基因对疟疾感染的反应是复杂的。两个小鼠基因座char1和char2此前已被证明可以控制峰值寄生虫血症和宿主存活。最近对宿主对小鼠疟疾反应的分析表明，几个基因座的作用是时间相关的。Char1和Char2在寄生虫血症高峰期之前起作用。对其他杂交组合的分析显示，在寄生虫血症高峰期的第二天，与17号染色体有显著的连锁关系。这种与H2相连的基因座在感染后期起作用，因此在清除循环中的寄生虫方面至关重要。该基因的克隆将有助于更好地了解宿主与寄生虫的相互作用，以及宿主基因在免疫应答过程中的表达动力学。
The action of host genes in response to malarial infection is complex. Two mouse loci, Char1, and Char2, have previously been shown to control peak parasitemia and host survival. Recent analysis of host response to mouse malaria has demonstrated that the action of several loci is time dependent. Char1 and Char2 act prior to peak parasitemia. Analysis of additional crosses revealed significant linkage to Chromosome 17 on the day following peak parasitemia. This H2-linked locus acts late in infection and is therefore crucial in clearing parasites from the circulation. The cloning of this gene will lead to a greater understanding of the host-parasite interaction, and the kinetics of host gene expression during an immune response.