Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
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DOI：
10.1038/nn1023
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发表时间：
2003-04-01
影响因子：
25
通讯作者：
Matsui, H
中科院分区：
文献类型：
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作者：
Tomizawa, K;Iga, N;Matsui, H
催产素是哺乳动物分娩和哺乳所必需的激素。在这里，我们展示了一个新的功能，催产素在造成可塑性变化的海马突触在母亲。在催产素灌注的海马脑片中，一列破伤风刺激诱导了持久的长时程增强（L-LTP）和环AMP反应元件结合蛋白（CREB）的磷酸化，MAP激酶抑制剂阻断了这些诱导。增加CREB磷酸化和L-LTP诱导的一列破伤风在多产小鼠海马中观察到催产素的应用。此外，脑室注射催产素在处女小鼠改善长期的空间学习在体内，而催产素拮抗剂在经产小鼠注射显着抑制改善的空间记忆，L-LTP和CREB磷酸化。这些发现表明，催产素是至关重要的参与改善海马依赖的学习和记忆在小鼠的母亲。
Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylation of cyclic AMP-responsive element binding protein (CREB), and MAP kinase inhibitors blocked these inductions. An increase in CREB phosphorylation and L-LTP induced by one-train tetanus were observed in the multiparous mouse hippocampus without oxytocin application. Furthermore, intracerebroventricular injection of oxytocin in virgin mice improved long-term spatial learning in vivo, whereas an injection of oxytocin antagonist in multiparous mice significantly inhibited the improved spatial memory, L-LTP and CREB phosphorylation. These findings indicate that oxytocin is critically involved in improving hippocampus-dependent learning and memory during motherhood in mice.