Fundamentals of Cellular Calcium Signaling: A Primer
Fundamentals of Cellular Calcium Signaling: A Primer
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DOI：
10.1101/cshperspect.a038802
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发表时间：
2020-01-01
影响因子：
7.2
通讯作者：
Bultynck, Geert
中科院分区：
文献类型：
--
作者：
Bootman, Martin D.;Bultynck, Geert
离子钙（Ca 2+）是最通用的细胞信使。所有细胞都使用Ca 2+信号来调节它们对外在和内在刺激的反应。细胞Ca 2+信号传导和/或Ca 2+稳态的改变可以颠覆生理过程，从而驱动病理结果。在过去的几十年中，活细胞的成像已经证明，Ca 2+信号在其频率，动力学，振幅和空间范围内编码信息。这些参数根据刺激的类型和强度以及细胞环境而改变。此外，很明显，不同的细胞类型产生广泛变化的Ca 2+信号，具有适合其生理功能的特性。本书讨论了细胞内Ca 2+信号和Ca 2+稳态的基本原理和机制。因此，我们引用了一些历史文章，以及最近的研究结果。简要概述了细胞内钙离子信号的核心特征，特别关注钙离子的储存和跨细胞膜的钙离子转运，以及钙离子信号激活下游效应系统的机制。
Ionized calcium (Ca2+) is the most versatile cellular messenger. All cells use Ca2+ signals to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular Ca2+ signaling and/or Ca2+ homeostasis can subvert physiological processes into driving pathological outcomes. Imaging of living cells over the past decades has demonstrated that Ca2+ signals encode information in their frequency, kinetics, amplitude, and spatial extent. These parameters alter depending on the type and intensity of stimulation, and cellular context. Moreover, it is evident that different cell types produce widely varying Ca2+ signals, with properties that suit their physiological functions. This primer discusses basic principles and mechanisms underlying cellular Ca2+ signaling and Ca2+ homeostasis. Consequently, we have cited some historical articles in addition to more recent findings. A brief summary of the core features of cellular Ca2+ signaling is provided, with particular focus on Ca2+ stores and Ca2+ transport across cellular membranes, as well as mechanisms by which Ca2+ signals activate downstream effector systems.