The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration.
The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration.
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DOI：
10.1038/s41598-017-05489-5
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发表时间：
2017-07-12
影响因子：
4.6
通讯作者：
Elliott DJ
中科院分区：
文献类型：
--
作者：
Munkley J;McClurg UL;Livermore KE;Ehrmann I;Knight B;Mccullagh P;Mcgrath J;Crundwell M;Harries LW;Leung HY;Mills IG;Robson CN;Rajan P;Elliott DJ
细胞迁移推动前列腺癌的细胞侵袭和转移进展，是导致死亡率和发病率的主要原因。然而，前列腺癌患者中驱动细胞迁移的机制还不完全清楚。我们先前发现癌症相关细胞迁移蛋白TSPAN1(TSPAN1)是前列腺癌雄激素调节的临床靶点。在这里，我们发现TSPAN1是由雄激素强烈诱导的，并且在前列腺癌中显著上调，相对于正常前列腺组织和良性前列腺增生症(BPH)。我们还首次表明，TSPAN1在前列腺癌细胞中的表达控制着参与细胞迁移的关键蛋白的表达。TSPAN1在DU145和PC3细胞中的稳定上调显著促进了细胞的迁移，并诱导了间充质标志物SLUG和ARF6的表达。我们的数据表明，TSPAN1是雄激素驱动的前列腺癌细胞存活和运动的贡献者。
Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostate cancer. Here we find that TSPAN1 is acutely induced by androgens, and is significantly upregulated in prostate cancer relative to both normal prostate tissue and benign prostate hyperplasia (BPH). We also show for the first time, that TSPAN1 expression in prostate cancer cells controls the expression of key proteins involved in cell migration. Stable upregulation of TSPAN1 in both DU145 and PC3 cells significantly increased cell migration and induced the expression of the mesenchymal markers SLUG and ARF6. Our data suggest TSPAN1 is an androgen-driven contributor to cell survival and motility in prostate cancer.
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将转录因子识别为单一的同源物2作为前列腺癌中潜在的生物标志物和免疫疗法靶标。
DOI：
10.1158/1078-0432.ccr-09-0911
发表时间：
2009-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Arredouani MS;Lu B;Bhasin M;Eljanne M;Yue W;Mosquera JM;Bubley GJ;Li V;Rubin MA;Libermann TA;Sanda MG
通讯作者：
Sanda MG
影响因子：
82.9
作者：
Beltran H;Prandi D;Mosquera JM;Benelli M;Puca L;Cyrta J;Marotz C;Giannopoulou E;Chakravarthi BV;Varambally S;Tomlins SA;Nanus DM;Tagawa ST;Van Allen EM;Elemento O;Sboner A;Garraway LA;Rubin MA;Demichelis F
通讯作者：
Demichelis F
影响因子：
--
作者：
Bhansali, Meenakshi;Zhou, Jun;Shemshedini, Lirim
通讯作者：
Shemshedini, Lirim
影响因子：
11.2
作者：
Greco, Celine;Bralet, Marie-Pierre;Boucheix, Claude
通讯作者：
Boucheix, Claude
DOI：
10.1016/j.jsbmb.2005.04.029
发表时间：
2005-08-01
影响因子：
4.1
作者：
Hååg, P;Bektic, J;Eder, IE
通讯作者：
Eder, IE