Seroprevalence of Maternal and Cord Antibodies Specific for Diphtheria, Tetanus, Pertussis, Measles, Mumps and Rubella in Shunyi, Beijing
Seroprevalence of Maternal and Cord Antibodies Specific for Diphtheria, Tetanus, Pertussis, Measles, Mumps and Rubella in Shunyi, Beijing
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北京市顺义地区白喉、破伤风、百日咳、麻疹、流行性腮腺炎、风疹母源及脐带特异性抗体血清阳性率分析
DOI：
10.1038/s41598-018-31283-y
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发表时间：
2018-08-29
影响因子：
4.6
通讯作者：
Yao, Kai-hu
中科院分区：
文献类型：
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作者：
Meng, Qing-hong;Liu, Ying;Yao, Kai-hu
母体抗体有助于保护幼儿在生命早期免受传染病的侵害。然而，在中国，育龄妇女的疫苗接种并不是常规的。因此，我们调查了中国孕妇和新生儿对疫苗可预防疾病的保护性免疫水平。2016年至2017年在北京共采集了194对孕产妇和脐带血样本。通过ELISA（Euroimmun，Lübeck，德国）测定白喉-破伤风-百日咳（DTP）和麻疹-腮腺炎-风疹（MMR）疫苗覆盖抗原的特异性抗体。分别以≥0.1 IU/ml（抗白喉）、>0.1 IU/ml（抗破伤风）、>40 IU/ml（抗百日咳毒素）、≥200 IU/l（抗麻疹）、≥45 RU/ml（抗腮腺炎）和≥10 IU/ml（抗风疹）作为临界值，评价新生儿IgG保护性浓度的百分比。结果表明，白喉、破伤风、百日咳、麻疹、腮腺炎和风疹的免疫保护率分别为61.3%、73.2%、97.4%、30.4%、65.5%和17.0%。只有1.0%和23.7%的新生儿分别对DTP或MMR的所有三个组成部分有保护作用。调查结果表明，大多数新生儿对白喉、破伤风、百日咳和腮腺炎易感，近三分之一的新生儿对麻疹没有免疫保护，约六分之一的新生儿受到风疹感染的威胁。这些数据支持在育龄妇女中进行百白破和马立克氏病疫苗的免疫规划。
Maternal antibodies contribute to the protection of young infants from infectious diseases during the early life. However, vaccinations for women of child-bearing age are not routine in China. Therefore, we investigated the level of protective immunity against vaccine preventable diseases in pregnant women and newborns in China. A total of 194 paired maternal and cord blood samples were collected in Beijing from 2016 to 2017. Antibodies specific for the antigens covered by diphtheria-tetanus-pertussis (DTP) and measles-mumps-rubella (MMR) vaccine were determined by ELISA (Euroimmun, Lübeck, Germany). The cut off value of ≥0.1 IU/ml (anti-diphtheria), >0.1 IU/ml (anti-tetanus), >40 IU/ml (anti-pertussis toxin), ≥200 IU/l (anti-measles), ≥45 RU/ml (anti-mumps) and ≥10 IU/ml (anti-rubella) were used to assess the percentage of newborns with protective IgG concentrations, respectively. The results revealed that 61.3%, 73.2%, 97.4%, 30.4%, 65.5% and 17.0% of newborns had no protection against diphtheria, tetanus, pertussis, measles, mumps and rubella. Only 1.0% and 23.7% of newborns had protection against all three components of DTP or MMR, respectively. The finding suggested that most of newborns were susceptible to diphtheria, tetanus, pertussis and mumps, almost one-third of this population had no immune protection against measles, and about one-sixth of them were under threat of rubella infection. These data supported the immunization program for DTP and MMR vaccine in women at child-bearing age.