The Registration Continuum in Clinical Science: A Guide Toward Transparent Practices
The Registration Continuum in Clinical Science: A Guide Toward Transparent Practices
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DOI：
10.1037/abn0000451
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发表时间：
2019-08-01
影响因子：
4.6
通讯作者：
Wright, Aidan G. C.
中科院分区：
文献类型：
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作者：
Benning, Stephen D.;Bachrach, Rachel L.;Wright, Aidan G. C.
临床科学家可以使用一系列注册工作，这些工作在数据收集和分析的披露和时间方面有所不同。从广义上讲，注册通过提供更强大，更强大的理论测试与特定方法以及更好地控制长期假阳性错误率而使调查人员受益。注册帮助临床研究人员思考围绕招募参与者，定义临床表型，处理合并症，处理缺失数据的带宽和保真度之间的紧张关系。分析丰富而复杂的数据。尤其是。注册有助于记录和证明特定研究设计决策背后的原因，尽管它也提供了注册具有特定终点的整个决策树的机会。创建更忠实的注册和标准操作程序可以提供判断临床研究者的科学技能和隆起的替代方法，因为研究注册增加了临床研究者工作的透明度。
Clinical scientists can use a continuum of registration efforts that vary in their disclosure and timing relative to data collection and analysis. Broadly speaking, registration benefits investigators by offering stronger, more powerful tests of theory with particular methods in tandem with better control of long-run false positive error rates. Registration helps clinical researchers in thinking through tensions between bandwidth and fidelity that surround recruiting participants, defining clinical phenotypes, handling comorbidity, treating missing data. and analyzing rich and complex data. In particular. registration helps record and justify the reasons behind specific study design decisions, though it also provides the opportunity to register entire decision trees with specific endpoints. Creating ever more faithful registrations and standard operating procedures may offer alternative methods of judging a clinical investigator's scientific skill and eminence because study registration increases the transparency of clinical researchers' work.