Oscillatory activity in the monkey hippocampus during visual exploration and memory formation
Oscillatory activity in the monkey hippocampus during visual exploration and memory formation
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DOI：
10.1073/pnas.1302351110
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发表时间：
2013-08-06
影响因子：
11.1
通讯作者：
Buffalo, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Jutras, Michael J.;Fries, Pascal;Buffalo, Elizabeth A.
灵长类动物通过眼球跳动来探索视觉世界。海马体是记忆的重要结构，它的神经元活动受到这种扫视活动的调节，但通过扫视进行视觉探索与记忆形成之间的关系尚不清楚。在这里，我们发现在执行识别记忆任务的猴子中，海马体的θ波段（3-12 Hz）振荡活动与跳眼活动之间存在联系。当猴子自由地探索新图像时，扫视产生theta波段相位重置，并且这种相位重置的可靠性预测了随后的识别。此外，刺激开始前θ波段功率的增强预示着更强的刺激编码。总之，这些数据表明，在灵长类动物中，海马体θ波段振荡与主动探索相一致，可能有助于建立刺激编码的最佳条件。
Primates explore the visual world through the use of saccadic eye movements. Neuronal activity in the hippocampus, a structure known to be essential for memory, is modulated by this saccadic activity, but the relationship between visual exploration through saccades and memory formation is not well understood. Here, we identify a link between theta-band (3-12 Hz) oscillatory activity in the hippocampus and saccadic activity in monkeys performing a recognition memory task. As monkeys freely explored novel images, saccades produced a theta-band phase reset, and the reliability of this phase reset was predictive of subsequent recognition. In addition, enhanced theta-band power before stimulus onset predicted stronger stimulus encoding. Together, these data suggest that hippocampal theta-band oscillations act in concert with active exploration in the primate and possibly serve to establish the optimal conditions for stimulus encoding.