Hydrogen Peroxide, Signaling in Disguise during Metal Phytotoxicity.
Hydrogen Peroxide, Signaling in Disguise during Metal Phytotoxicity.
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DOI：
10.3389/fpls.2016.00470
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发表时间：
2016
影响因子：
5.6
通讯作者：
Keunen E
中科院分区：
文献类型：
--
作者：
Cuypers A;Hendrix S;Amaral Dos Reis R;De Smet S;Deckers J;Gielen H;Jozefczak M;Loix C;Vercampt H;Vangronsveld J;Keunen E
暴露于过量金属的植物面临着活性氧 (ROS) 生成增加的挑战，例如超氧化物 ()、过氧化氢 (H2O2) 和羟基自由基 (·OH)。这种氧化挑战的机制通常取决于金属的特定特性，并可能在压力感知、信号传导和适应中发挥作用。尽管ROS最初被认为是有毒化合物，会对各种细胞结构造成损害，但它们作为信号分子的作用在过去十年中成为了深入研究的主题。过氧化氢在信号传导中尤其重要，因为它的毒性相对较低、寿命较长且能够穿过细胞膜。它的产生和大量酶促和代谢抗氧化剂的清除之间的微妙平衡对于多种信号级联的发生至关重要，最终导致植物适应金属胁迫。在这篇综述中，介绍了我们目前关于 ROS 在金属暴露植物中的双重作用的知识。提供了 H2O2 与植物金属耐受性之间关系的证据。此外，重点放在了解金属诱导的 H2O2 产生导致的细胞损伤和下游信号反应方面的最新进展。最后，特别关注 H2O2 与其他信号成分（例如转录因子、丝裂原激活蛋白激酶、植物激素和调节系统（例如 microRNA））之间的相互作用。这些反应可能是金属诱导植物衰老的基础。阐明金属胁迫期间激活的信号网络是污染土壤植物修复等应用技术取得进展的关键一步。
Plants exposed to excess metals are challenged by an increased generation of reactive oxygen species (ROS) such as superoxide (), hydrogen peroxide (H2O2) and the hydroxyl radical (•OH). The mechanisms underlying this oxidative challenge are often dependent on metal-specific properties and might play a role in stress perception, signaling and acclimation. Although ROS were initially considered as toxic compounds causing damage to various cellular structures, their role as signaling molecules became a topic of intense research over the last decade. Hydrogen peroxide in particular is important in signaling because of its relatively low toxicity, long lifespan and its ability to cross cellular membranes. The delicate balance between its production and scavenging by a plethora of enzymatic and metabolic antioxidants is crucial in the onset of diverse signaling cascades that finally lead to plant acclimation to metal stress. In this review, our current knowledge on the dual role of ROS in metal-exposed plants is presented. Evidence for a relationship between H2O2 and plant metal tolerance is provided. Furthermore, emphasis is put on recent advances in understanding cellular damage and downstream signaling responses as a result of metal-induced H2O2 production. Finally, special attention is paid to the interaction between H2O2 and other signaling components such as transcription factors, mitogen-activated protein kinases, phytohormones and regulating systems (e.g. microRNAs). These responses potentially underlie metal-induced senescence in plants. Elucidating the signaling network activated during metal stress is a pivotal step to make progress in applied technologies like phytoremediation of polluted soils.