Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.
Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.
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DOI：
10.1371/journal.pone.0065636
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Alda M
中科院分区：
文献类型：
--
作者：
Manchia M;Adli M;Akula N;Ardau R;Aubry JM;Backlund L;Banzato CE;Baune BT;Bellivier F;Bengesser S;Biernacka JM;Brichant-Petitjean C;Bui E;Calkin CV;Cheng AT;Chillotti C;Cichon S;Clark S;Czerski PM;Dantas C;Zompo MD;Depaulo JR;Detera-Wadleigh SD;Etain B;Falkai P;Frisén L;Frye MA;Fullerton J;Gard S;Garnham J;Goes FS;Grof P;Gruber O;Hashimoto R;Hauser J;Heilbronner U;Hoban R;Hou L;Jamain S;Kahn JP;Kassem L;Kato T;Kelsoe JR;Kittel-Schneider S;Kliwicki S;Kuo PH;Kusumi I;Laje G;Lavebratt C;Leboyer M;Leckband SG;López Jaramillo CA;Maj M;Malafosse A;Martinsson L;Masui T;Mitchell PB;Mondimore F;Monteleone P;Nallet A;Neuner M;Novák T;O'Donovan C;Osby U;Ozaki N;Perlis RH;Pfennig A;Potash JB;Reich-Erkelenz D;Reif A;Reininghaus E;Richardson S;Rouleau GA;Rybakowski JK;Schalling M;Schofield PR;Schubert OK;Schweizer B;Seemüller F;Grigoroiu-Serbanescu M;Severino G;Seymour LR;Slaney C;Smoller JW;Squassina A;Stamm T;Steele J;Stopkova P;Tighe SK;Tortorella A;Turecki G;Wray NR;Wright A;Zandi PP;Zilles D;Bauer M;Rietschel M;McMahon FJ;Schulze TG;Alda M
双相情感障碍（BD）患者对锂盐维持治疗的反应评估因治疗时间长短不一、临床病程不可预测以及依从性不一致而变得复杂。文献中已经提出了评估锂反应的前瞻性和回顾性方法。在这项研究中，我们报告了锂遗传学联盟 (ConLiGen) 研究中目前使用的“双向情感障碍研究对象长期治疗反应回顾性标准”量表的关键表型测量。 29 个 ConLiGen 中心参与了两阶段病例插图评级程序，以检查锂反应的评级者间一致性 [Kappa (κ)] 和可靠性 [组内相关系数 (ICC)]。带注释的第一轮小插图和评级指南已分发给专家研究临床医生，用于两个阶段之间的培训目的。此外，我们使用混合模型分析了 1,308 名患者的治疗反应评分的分布特性。在第一组和第二组小插图中，各站点之间显示出显着和中等程度的一致性（分别为 κ = 0.66 和 κ = 0.54），但训练没有显着改善。然而，使用 A 分数作为数量性状的反应定义并选择 B 标准为 4 或更低的病例显示两个阶段之间有所改善（分别为 ICC1 = 0.71 和 ICC2 = 0.75）。分数分布的混合模型表明了三个亚群（完全响应者、部分响应者、无响应者）。我们确定了锂反应的两种定义，一种是二分的，另一种是连续的，具有中等至显着的评估者间一致性和可靠性。锂反应的准确表型测量对于正在进行的 ConLiGen 药物基因组研究至关重要。
The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the “Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder” scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling. Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders). We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.
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影响因子：
3.6
作者：
Cheniaux, Elie;Landeira-Fernandez, J.;Versiani, Marcio
通讯作者：
Versiani, Marcio
DOI：
10.1177/070674370705200606
发表时间：
2007-06-01
影响因子：
4
作者：
Duffy, Anne;Alda, Martin;Grof, Paul
通讯作者：
Grof, Paul
影响因子：
17.7
作者：
Maj, M;Pirozzi, R;Bartoli, L
通讯作者：
Bartoli, L
影响因子：
11
作者：
Etain, B.;Mathieu, F.;Leboyer, M.
通讯作者：
Leboyer, M.
DOI：
10.1007/s00406-012-0323-x
发表时间：
2012-06-01
影响因子：
4.7
作者：
Fountoulakis, Konstantinos N.;Kasper, Siegfried;Vieta, Eduard
通讯作者：
Vieta, Eduard