Synthesis and Catalytic Activity of Amino Acids and Metallopeptides with Catalytically Active Metallocyclic Side Chains.
Synthesis and Catalytic Activity of Amino Acids and Metallopeptides with Catalytically Active Metallocyclic Side Chains.
复制标题
具有催化活性金属环侧链的氨基酸和金属肽的合成和催化活性。
DOI：
10.1021/om300848p
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发表时间：
2012
期刊：
影响因子：
2.8
通讯作者：
Lewis,JaredC
中科院分区：
文献类型：
--
作者：
Zhong,Zhihui;Yang,Hao;Zhang,Chen;Lewis,JaredC
介绍了两种制备具有催化活性的有机金属侧链的氨基酸的方法。这些方法的显著之处在于它们提供了结构上类似于天然存在的氨基酸的游离或N-保护的化合物。N-保护的有机金属氨基酸与标准肽偶联条件相容，并且可用于制备催化活性金属肽。
Two approaches to prepare amino acids with catalytically active organometallic side chains are presented. These methods are notable in that they provide access either free or N-protected compounds that are structurally analogous to naturally occurring amino acids. The N-protected organometallic amino acids are compatible with standard peptide coupling conditions and can be used to prepare catalytically active metallopeptides.