X-chromosome heteromorphism and appearance of meiosis in the rat fetal ovary.
X-chromosome heteromorphism and appearance of meiosis in the rat fetal ovary.
复制标题
大鼠胎儿卵巢中 X 染色体异态性和减数分裂的出现。
DOI：
10.1016/0012-1606(82)90229-9
复制
发表时间：
1982
影响因子：
2.7
通讯作者：
Ducayen,M
中科院分区：
文献类型：
--
作者：
Jagiello,G;Downey,S;Ducayen,M
对胎鼠卵子发生进行了检查，试图检验减数分裂开始需要两条功能性 X 染色体的假设。生殖细胞中巴尔小体的存在被认为是一条不活跃的X染色体的证据，并且细线卵母细胞的检测被认为是减数分裂前期建立的标准。结果发现，妊娠第16天，3.9%的生殖细胞是细线卵母细胞，但巴尔体阳性卵原细胞的发生率持续保持在9.9%。第 17 天，细线卵母细胞增加至 26.6%，巴尔体阳性卵原细胞减少至 3.5%。结论是，X 染色体重新激活虽然发生在减数分裂开始期间的某个时间，但并不是起始事件。
Fetal rat oogenesis was examined attempting to test the hypothesis that two functional X chromosomes are required for the onset of meiosis. The presence of a Barr body in germ cells was considered to be evidence for one inactive X chromosome and the detection of leptotene oocytes as the criterion for the establishment of meiotic prophase. It was found that on Day 16 of gestation, 3.9% of the germ cells were leptotene oocytes, but the incidence of Barr body-positive oogonia persisted at 9.9%. On Day 17, the leptotene oocytes had increased to 26.6% and the Barr body-positive oogonia had decreased to 3.5%. It was concluded that X-chromosome reactivation, though occurring at some time during the onset of meiosis, was not the initiating event.