Mineralization and mechanical properties of the canine mandible distraction wound following acute molding
Mineralization and mechanical properties of the canine mandible distraction wound following acute molding
复制标题
DOI：
10.1016/j.ijom.2006.03.018
复制
发表时间：
2006-09-01
影响因子：
2.4
通讯作者：
Rahn, B.
中科院分区：
文献类型：
--
作者：
Kunz, C.;Adolphs, N.;Rahn, B.
为探讨牵张后即刻急性单步牵张对再生骨的力学性能和矿化的影响，将自制牵张器放置在15只比格犬的下颌角处，同时压缩和拉伸完成线性牵张后的再生骨。将动物分为3组(n=5)：第1组和第2组进行再生操作，第3组保持直线位置。术后42天(第1组)和90天(第2组和第3组)处死动物。在Instron(R)测试框架中评估力学性能，并通过定量计算机断层扫描和三维评估(Scion Image(R)处理和分析软件)对骨密度进行量化。6周后，25%的标本达到硬挺度，为未手术的参考半下颌骨平均值的90%。经过13周的固位期后，62.5%的标本与参考标本一样僵硬。在稳定的条件下愈合13周的操纵性再生，与单纯线性牵张的标本具有相同的机械性能。在6周后，拉伸区可能会出现暂时但并不明显的骨愈合延迟，这表明这一区域比受压区更为关键。
To investigate the influence of an acute single step callus manipulation immediately after distraction on mechanical properties and mineralization of the regenerate, custom made distraction devices were bilaterally placed in the mandibular angle of 15 beagle dogs, allowing to simultaneously compress and stretch the regenerate after completed linear distraction. The animals were divided in three groups (n = 5): Group 1 and 2 underwent manipulation of the regenerate, group 3 remained in a linear position. After 42 (group 1) and 90 (group 2 and 3) days of consolidation the animals were sacrificed. The mechanical properties were assessed in an Instron(R) testframe and bone density quantified by quantitative computed tomography and three-dimensionally assessed (Scion Image(R) processing and analysis software).After 6 weeks of consolidation 25% of the specimens reached a stiffness which was >= 90% of the mean values of the unoperated reference hemi-mandibles. After a 13 week consolidation period, 62.5% were as stiff as the referenced specimens. Manipulated regenerates, allowed to heal under stable conditions for 13 weeks, had the same mechanical properties as specimens that underwent pure linear distraction. A temporary but not significant delay of osseous healing had to be postulated for the stretched zone after 6 weeks, indicating this area to be more critical than the compressed area.