Synaptic integrative mechanisms for spatial cognition.

Synaptic integrative mechanisms for spatial cognition.
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空间认知的突触整合机制。

DOI:
10.1038/nn.4652
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发表时间:
2017
影响因子:
25
通讯作者:
Schmidt-Hieber C
Schmidt-Hieber C
中科院分区:
医学1区
文献类型:
--
作者:
Schmidt-Hieber C

文献摘要

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突触整合机制对大脑中的电信号传导具有深远的影响,虽然在很大程度上隐藏在观察神经元尖峰活动的记录方法中,但对于信息的编码、存储和检索可能至关重要。在这里,我们回顾了突触整合机制在位置和网格场的选择、生成和可塑性以及空间表示的相关时间代码中的作用。我们概述了空间计算和记忆假设模型测试中的突出问题和挑战。
Synaptic integrative mechanisms have profound effects on electrical signaling in the brain that, although largely hidden from recording methods that observe the spiking activity of neurons, may be critical for the encoding, storage and retrieval of information. Here we review roles for synaptic integrative mechanisms in the selection, generation and plasticity of place and grid fields, and in related temporal codes for the representation of space. We outline outstanding questions and challenges in the testing of hypothesized models for spatial computation and memory.