Uniform and accelerated degradation of pure iron patterned by Pt disc arrays.
Uniform and accelerated degradation of pure iron patterned by Pt disc arrays.
复制标题
Pt 圆盘阵列图案纯铁的均匀加速降解
DOI：
10.1038/srep23627
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发表时间：
2016-04-01
影响因子：
4.6
通讯作者：
Zheng Y
中科院分区：
文献类型：
--
作者：
Huang T;Zheng Y
纯铁已被证实是一种有前途的可生物降解金属。但要达到临床要求，需加快纯铁的降解速度。在纯铁表面镀制了Φ20 μm × S5 μm和Φ4 μm × S4 μm两种不同尺寸的铂片阵列。腐蚀试验表明，铂片与铁基体形成大量原电池，加速了纯铁的降解。同时，由于铂片的形状、尺寸和分布具有可设计性，因此通过涂覆铂片可以有效地控制纯铁的降解速率和降解均匀性。细胞毒性实验结果显示，铂盘图案化纯铁对人脐静脉内皮细胞几乎没有毒性，但对血管平滑肌细胞增殖有明显抑制作用。此外，铂盘图案化纯铁的溶血率低于1%。此外，铂片还有效地减少了粘附的血小板的数量。这些结果表明，铂盘图案化是加速纯铁降解和改善生物相容性的有效途径。
Pure iron has been confirmed as a promising biodegradable metal. However, the degradation rate of pure iron should be accelerated to meet the clinical requirements. In this work, two different designs of platinum disc arrays, including sizes of Φ20 μm × S5 μm and Φ4 μm × S4 μm, have been coated on the surface of pure iron. Corrosion tests showed the platinum discs formed plenty of galvanic cells with the iron matrix which significantly accelerated the degradation of pure iron. Simultaneously, due to the designability of the shape, size as well as distribution of Pt discs, the degradation rate as well as degradation uniformity of pure iron can be effectively controlled by coating with platinum discs. The cytotoxicity test results unveiled that Pt discs patterned pure iron exhibited almost no toxicity to human umbilical vein endothelial cells, but a significant inhibition on proliferation of vascular smooth muscle cells. In addition, the hemolysis rate of Pt discs patterned pure iron was lower than 1%. Moreover, Pt discs also effectively reduced the number of adhered platelets. All these results indicated that Pt discs patterning is an effective way to accelerate degradation and improve biocompatibility of pure iron.