ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension
ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension
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ALDH2 基因 rs671 多态性可能降低原发性高血压的风险
DOI：
10.1536/ihj.19-259
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发表时间：
2020-05-01
影响因子：
1.5
通讯作者：
Chen, Tan
中科院分区：
文献类型：
--
作者：
Mei, Xiao-Fei;Hu, Sheng-Da;Chen, Tan
乙醛脱氢酶2（ALDH 2）rs671 G>A多态性可影响ALDH 2活性，并可能与原发性高血压（EH）的发病风险有关。本文检索PubMed、Embase和中国知网数据库中关于ALDH 2基因与EH的相关性研究。我们使用Newcastle-Ottawa量表来评估研究的质量。利用比值比和95%可信区间计算ALDH 2 rs671突变与EH的相关强度。对纳入的12篇文献（8153例病例，10,162例对照）进行了亚组分析和敏感性分析，并对发表偏倚进行了评价。我们的荟萃分析显示ALDH 2 rs671多态性与EH在4种遗传模型（等位基因模型、纯合子模型、杂合子模型和显性模型）中存在显著关联，而在隐性模型中没有显示这种关联。然而，仍然可以看到风险降低的趋势。此外，在所有5种遗传模型中，rs671基因突变与EH的相关性在男性组均高于女性组，提示ALDH 2基因rs671 G>A多态性可能降低EH的风险。此外，对Eli的易感性在男性中降低，但在女性中不降低。作为ALDH 2的变体。rs671 G>A可能是EH基因治疗的一个有吸引力的候选基因。结论ALDH 2基因与原发性高血压之间存在基因-基因、基因-环境交互作用，需要进一步的病例对照研究进一步证实。
Aldehyde dehydrogenase-2 (ALDH2) rs671 G>A polymorphism can influence the activity of ALDH2 and may be associated with the risk of essential hypertension (EH). Although many previous studies have explored such a relationship, the conclusion is still controversial.The PubMed, Embase, and China National Knowledge Infrastructure databases were searched on the ALDH2 gene and EH. We used the Newcastle-Ottawa Scale to evaluate the quality of the study. Then we calculated the strength of relationship between ALDH2 rs671 mutation and EH by utilizing odds ratios and 95% confidence intervals. Besides, subgroup analysis and sensitivity analysis were performed and the publication bias was assessed.There were 12 studies containing 8153 cases and 10,162 controls. Our meta-analysis showed significant association between ALDH2 rs671 polymorphism and EH in four genetic models (the allele model, the homozygote model, the heterozygote model, and the dominant model), whereas it did not indicate this connection in the recessive model. However, a trend of decreased risk still could be seen. Furthermore, we also found an obvious association between rs671 mutation and the risk of EH in the male group than in the female group in all five genetic models.We concluded that ALDH2 rs671 G>A polymorphism may decrease the risk of EH. Furthermore, susceptibility to Eli reduced in males but not in females. As a variant in ALDH2. rs671 G>A could be an attractive candidate for genetic therapy of EH. In addition, more case-control studies should be conducted to strengthen our conclusion and evaluate the gene-gene and gene-environment interactions between the ALDH2 gene and EH.