Immunologically silent cancer clone transmission from mother to offspring
Immunologically silent cancer clone transmission from mother to offspring
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DOI：
10.1073/pnas.0904658106
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发表时间：
2009-10-20
影响因子：
11.1
通讯作者：
Mizutani, Shuki
中科院分区：
文献类型：
--
作者：
Isoda, Takeshi;Ford, Anthony M.;Mizutani, Shuki
在过去的100年里，记录了罕见的可能通过母婴传播癌症的病例，但共享癌症克隆的证据一直非常有限。我们为白血病细胞克隆的母子在子宫内传播提供了遗传学证据。母亲和婴儿的癌症克隆共享相同的独特的BCR-ABL1基因组融合序列，表明共同的单细胞起源。婴幼儿癌症中的微卫星标记均来自母体。此外，婴儿、母体来源的癌细胞在一份6p染色体上有一个重大缺失，其中包括婴儿没有遗传的(即婴儿外来的)HLA等位基因的缺失，这表明可能存在免疫逃避的机制。
Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally- derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.