Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway
Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway
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DOI：
10.1016/s1074-7613(03)00321-2
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发表时间：
2003-12-01
期刊：
影响因子：
32.4
通讯作者：
Molina, H
中科院分区：
文献类型：
--
作者：
Mao, DL;Wu, XB;Molina, H
由于胎儿母体耐受力异常而导致妊娠失败的因素尚不清楚。在这里，我们描述了胎盘形成的明显缺陷和随后的妊娠丢失，仅依赖于补体替代途径的激活和母体 C3 提供的效应机制。令人惊讶的是，这种作用独立于其他补体激活途径和其他补体成分提供的效应机制。这些发现为了解先天免疫系统在人类妊娠失败（一种常见的临床结果）中的作用提供了重要的见解。
Factors involved in pregnancy failure due to abnormal fetomaternal tolerance are poorly understood. Here we describe distinct defects in placenta formation and subsequent pregnancy loss solely dependent on the activation of the complement alternative pathway and the effector mechanisms provided by the maternal C3. Surprisingly, this effect is independent of other complement activation pathways and of the effector mechanisms provided by other complement components. These findings provide significant insight into the role of the innate immune system in human pregnancy failure, a frequent clinical outcome.