Increased interleukin-10 mRNA expression in tumor-bearing or persistently lymphocytotic animals infected with bovine leukemia virus
Increased interleukin-10 mRNA expression in tumor-bearing or persistently lymphocytotic animals infected with bovine leukemia virus
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DOI：
10.1128/jvi.70.8.5706-5710.1996
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发表时间：
1996-08-01
影响因子：
5.4
通讯作者：
Splitter, GA
中科院分区：
文献类型：
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作者：
Pyeon, D;OReilly, KL;Splitter, GA
白介素-10 (IL-10) 由 Th2 辅助 T 细胞、B 细胞和巨噬细胞产生，可以抑制 Th1 细胞产生细胞因子，增强 B 细胞增殖和分化。在这里，我们发现，患有晚期疾病的牛白血病病毒感染动物的外周血单核细胞（PBMC）比未感染或处于疾病早期的动物表达更多的IL-10 mRNA。相反，1型细胞因子、IL-2和γ干扰素的数量随着疾病进展而减少。此外，我们观察到IL-10主要由单核细胞/巨噬细胞而不是B淋巴细胞持续表达。淋巴细胞动物，这一观察结果支持单核细胞/巨噬细胞在牛白血病病毒感染进展中的作用，并且重要的是，表明增殖的 B 细胞不是 IL-10 表达的来源。这些发现表明，单核细胞/巨噬细胞产生的 IL-10 可能会影响发生持续性 B 细胞淋巴细胞增多症或 B 细胞淋巴肉瘤的动物的牛白血病进展。
Interleukin-10 (IL-10), produced by Th2 helper T cells, B cells, and macrophages, can inhibit cytokine production by Th1 cells and enhance B-cell proliferation and differentiation. Here, we show that peripheral blood mononuclear cells (PBMCs) from bovine leukemia virus-infected animals with late-stage disease express considerably more IL-10 mRNA than animals that are not infected or that are in the early stages of disease, In contrast, the quantities of type 1 cytokines, IL-2 and gamma interferon, decrease with disease progression, In addition, we observed that IL-10 is expressed principally by monocytes/macrophages, not B lymphocytes, in persistently lymphocytotic animals, This observation supports a role for monocytes/macrophages in progression of bovine leukemia virus infection and, of importance, indicates that proliferating B cells are not the source of IL-10 expression, These findings suggest that IL-10 produced by monocytes/macrophages may influence the progression of bovine leukosis in animals that develop persistent lymphocytosis of B cells or B-cell lymphosarcoma.