CHARACTERIZATION OF CANINE FOCAL LIVER LESIONS WITH CONTRAST-ENHANCED ULTRASOUND USING A NOVEL CONTRAST AGENT-SONAZOID
CHARACTERIZATION OF CANINE FOCAL LIVER LESIONS WITH CONTRAST-ENHANCED ULTRASOUND USING A NOVEL CONTRAST AGENT-SONAZOID
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DOI：
10.1111/j.1740-8261.2009.01515.x
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发表时间：
2009-03-01
影响因子：
1.7
通讯作者：
Tsujimoto, Hajime
中科院分区：
文献类型：
--
作者：
Kanemoto, Hideyuki;Ohno, Koichi;Tsujimoto, Hajime
对比增强超声使用Sonazoid，一种新的造影剂与肝脏特异性Kupffer阶段，在犬局灶性肝病变进行了评价。25只狗的肝脏肿块静脉注射Sonazoid，并在动脉，门静脉和实质阶段的增强模式的特点。在所有恶性病变中观察到实质期病变的增强缺陷，而9个良性病变中只有1个有充盈缺陷。存在充盈缺损对恶性肿瘤的诊断价值具有统计学意义（100%敏感性，88.9%特异性，94.1%阳性预测值，100%阴性预测值），与门脉期或延迟期低增强的诊断价值相同。缺损类型（透明或不规则缺损）具有依赖性（P
Contrast-enhanced ultrasound using Sonazoid, a novel contrast medium with a liver-specific Kupffer phase, was evaluated in canine focal liver lesions Twenty-five dogs with a liver mass were given intravenous Sonazoid, and the enhancement pattern in the arterial, portal, and parenchymal phase was characterized. An enhancement defect in the lesion in the parenchymal phase was observed in all malignant lesions, whereas only one of nine benign lesions had a filling defect. The diagnostic value of the presence of a filling defect for malignancy was statistically significant (100% sensitivity, 88.9% specificity, 94.1% positive predictive value, 100% negative predictive value), and was equal to that of hypoenhancement in the portal or delayed phase. The defect pattern (clear or irregular defect) was dependent (P