Diabetes incidence does not differ between subjects with and without high depressive symptoms-5-year follow-up results of the Heinz Nixdorf Recall Study
Diabetes incidence does not differ between subjects with and without high depressive symptoms-5-year follow-up results of the Heinz Nixdorf Recall Study
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DOI：
10.1111/j.1464-5491.2012.03724.x
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发表时间：
2013-01-01
影响因子：
3.5
通讯作者：
Moebus, S.
中科院分区：
文献类型：
--
作者：
Icks, A.;Albers, B.;Moebus, S.
迪亚贝特。地中海医院。30,6569(2013)摘要目标横断面研究一直报告有证据表明糖尿病和抑郁障碍之间存在联系。然而，只有有限的前瞻性研究检查了这种联系，报告了相互矛盾的结果。在一项基于人群的队列研究中，我们比较了有和没有高度抑郁症状的参与者的糖尿病累积发病率。方法我们分析了德国Heinz Nixdorf回顾研究对3547名非糖尿病参与者的5年随访数据[平均年龄58.8(SD 7.6)岁，47.5%男性]。抑郁症状的定义使用流行病学研究中心抑郁量表(分界点=17)。糖尿病(已确诊或以前未被发现)是通过自我报告的医生诊断的糖尿病、药物和高血糖水平来确定的。我们用95%的可信区间估计了5年的累积发病率，并用多元Logistic回归模型计算了优势比，调整了年龄、性别、体力活动、吸烟、与伴侣同住或不与伴侣同住和教育水平。结果基线时有高度抑郁症状的受试者糖尿病累积发生率为9.2%(95%可信区间6.312.8)，无抑郁症状受试者的累积糖尿病患病率为9.0%(95%可信区间8.010.0)。有抑郁症状的参与者与无抑郁症状的参与者相比，年龄和性别调整后患糖尿病的优势比为1.13[95%可信区间0.771.68；完全调整后的比值比1.11(95%可信区间0.741.65)]。在其他几项敏感性分析中，这些结果并没有实质性的变化。结论在5年的随访期内，我们的研究没有显示出有高度抑郁症状的个体与没有高度抑郁症状的个体相比，患糖尿病的风险显著增加。迪亚贝特。地中海医院。30，65-69(2013)
Diabet. Med. 30, 6569 (2013) Abstract Aims Cross-sectional studies have consistently reported evidence for an association between diabetes and depressive disorders. However, only limited prospective studies have examined this association, reporting conflicting results. In a population-based cohort study, we compared cumulative incidences of diabetes between participants with and without high depressive symptoms. Method We analysed the 5-year follow-up data from the German Heinz Nixdorf Recall study of 3547 participants without diabetes at baseline [mean age 58.8 (sd 7.6) years, 47.5% male]. Depressive symptoms were defined using the Centre for Epidemiologic Studies Depression scale (cut point = 17). Diabetes (diagnosed or previously undetected) was identified by self-reported physician-diagnosed diabetes, medication and high blood glucose levels. We estimated 5-year cumulative incidences with 95% confidence intervals and fitted multiple logistic regression models to calculate the odds ratios, adjusted for age, sex, physical activity, smoking, living with or without partner, and educational level. Results The cumulative incidence of diabetes was 9.2% (95% CI 6.312.8) in participants with high depressive symptoms at baseline and 9.0% (95% CI 8.010.0) in participants without these symptoms. The age- and sex-adjusted odds ratio of diabetes in participants with depressive symptoms compared with those without was 1.13 [95% CI 0.771.68; fully adjusted 1.11 (95% CI 0.741.65)]. These results did not substantially change in several additional sensitivity analyses. Conclusion Our study did not show a significantly increased risk of developing diabetes in individuals with high depressive symptoms compared with those without high depressive symptoms during a 5-year follow-up period. Diabet. Med. 30, 65-69 (2013)