A pilot study on the effects of sodium oxybate on sleep architecture and daytime alertness in narcolepsy
A pilot study on the effects of sodium oxybate on sleep architecture and daytime alertness in narcolepsy
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DOI：
10.1093/sleep/27.7.1327
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发表时间：
2004-11-01
期刊：
影响因子：
5.6
通讯作者：
Ristanovic, R
中科院分区：
文献类型：
--
作者：
Mamelak, M;Black, J;Ristanovic, R
研究目的：观察夜间给药氧酸钠对发作性睡病患者睡眠结构的影响。设计：开放标签研究。环境：四家经过认证的睡眠诊所。参与者：25例发作性睡猝倒的成年患者。干预措施：患者从先前使用的抗癫痫药物中断奶，并在10周内增加每晚剂量的氢氧化钠：4周4.5 g， 2周6 g， 2周7.5 g， 2周9 g。使用夜间多导睡眠图、艾普沃斯嗜睡量表、清醒维持测试和发作性睡病症状问卷来测量氧酸钠的效果。结果：夜间给药后，慢波睡眠和δ波功率呈剂量相关增加，快速眼动睡眠先增加后减少，夜间觉醒次数减少，日间睡眠潜伏期增加。通过维持清醒测试、Epworth嗜睡量表和发作性睡病症状问卷来测量白天症状的显著改善。结论：嗜眠症患者夜间给予氧酸钠可显著改善睡眠结构，同时显著改善白天功能。
Study Objectives: To measure the effect of nocturnal sodium oxybate administration on sleep architecture in patients with narcolepsy.Design: Open-label study.Setting: Four accredited sleep clinics.Participants: 25 adult patients with narcolepsy-cataplexy.Interventions: Patients were weaned from previously used anticataplectic medications and administered increasing nightly doses of sodium oxybate over a 10-week period: 4.5 g for 4 weeks, 6 g for 2 weeks, 7.5 g for 2 weeks, and 9 g for 2 weeks. The effect of sodium oxybate was measured using nocturnal polysomnograms, the Epworth Sleepiness Scale, the Maintenance of Wakefulness Test, and a narcolepsy symptoms questionnaire.Results: The nightly administration of sodium oxybate produced dose-related increases in slow-wave sleep and delta power, rapid eye movement sleep increased initially and then decreased in a dose-related manner, nocturnal awakenings decreased, and daytime sleep latency increased. Significant improvements in daytime symptoms were measured by the Maintenance of Wakefulness Test, the Epworth Sleepiness Scale, and the narcolepsy symptom questionnaire.Conclusions: Nocturnal administration of sodium oxybate in patients with narcolepsy produces significant improvements in sleep architecture, which coincide with significant improvements in daytime functioning.