Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations.
Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations.
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Admix-kit：用于混合群体遗传分析的集成工具包和管道。
DOI：
10.1101/2023.09.30.560263
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Shortt,J
中科院分区：
文献类型：
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作者：
Hou,Kangcheng;Gogarten,Stephanie;Kim,Joohyun;Hua,Xing;Dias,Julie-Alexia;Sun,Quan;Wang,Ying;Tan,Taotao;PolygenicRiskMethodsinDiversePopulations(PRIMED)ConsortiumMethodsWorkingGroup;Atkinson,ElizabethG;Martin,Alicia;Shortt,J
摘要 混合人群因其独特且多样化的遗传背景，在遗传学研究中往往代表性不足。这种疏忽不仅限制了我们的理解，而且加剧了现有的健康差距。一个主要障碍是缺乏针对混合群体遗传研究特殊挑战的有效工具。在这里，我们展示了 admix-kit，这是一个用于混合群体遗传分析的集成工具包和管道。 Admix-kit 实现了一套方法来促进混合群体中的基因型和表型模拟、关联测试、遗传结构推断和多基因评分。可用性和实现Admix-kit 包是开源的，可在 https://github.com/Kang ChengHou/admix-kit 上获取。此外，用户可以使用为混合基因型模拟设计的管道，网址为 https://github.com/UW-GAC/admix-kit_workflow。
SummaryAdmixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic studies of admixed populations. Here, we present admix-kit, an integrated toolkit and pipeline for genetic analyses of admixed populations. Admix-kit implements a suite of methods to facilitate genotype and phenotype simulation, association testing, genetic architecture inference, and polygenic scoring in admixed populations.Availability and implementationAdmix-kit package is open-source and available at https://github.com/KangchengHou/admix-kit. Additionally, users can use the pipeline designed for admixed genotype simulation available at https://github.com/UW-GAC/admix-kit_workflow.