Variant rs2237892 of KCNQ1 Is Potentially Associated with Hypertension and Macrovascular Complications in Type 2 Diabetes Mellitus in A Chinese Han Population.
Variant rs2237892 of KCNQ1 Is Potentially Associated with Hypertension and Macrovascular Complications in Type 2 Diabetes Mellitus in A Chinese Han Population.
复制标题
KCNQ1 的变异 rs2237892 可能与中国汉族人群 2 型糖尿病的高血压和大血管并发症相关
DOI：
10.1016/j.gpb.2015.05.004
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Li W
中科院分区：
文献类型：
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作者：
Zhang W;Wang H;Guan X;Niu Q;Li W
通过全基因组关联研究，KCNQ1已被确定为亚洲人群2型糖尿病(T2 DM)的易感基因。然而，KCNQ1基因多态性与T2 DM并发症的相关性研究尚不清楚。为了进一步分析KCNQ1和TD2M的单核苷酸多态(SNP)rs2237892不同等位基因与其并发症的关系，我们在中国汉族人群中进行了病例对照研究。Rs2237892变异的C等位基因与T2 DM的易感性有关(优势比[OR]，1.45；95%可信区间[CI]，1.20~1.75)。CT(OR，1.97；95%CI，1.24~3.15)和CC(OR，2.49；95%CI，1.57~3.95)与T2 DM的风险增加相关。在调整了年龄、性别和体重指数后，进行了多元回归分析。研究发现，CC基因携带者的收缩压(P=0.015)、高血压患病率(P=0.037)和大血管疾病的风险(OR，2.10；CI，1.00-4.45)显著高于CT或TT基因携带者。因此，我们的数据支持KCNQ1与T2 DM的风险增加相关，并可能导致携带风险等位基因C的T2 DM患者更高的高血压和大血管并发症的发生率，尽管这需要在更大的人群中进一步证实。
KCNQ1 has been identified as a susceptibility gene of type 2 diabetes mellitus (T2DM) in Asian populations through genome-wide association studies. However, studies on the association between gene polymorphism of KCNQ1 and T2DM complications remain unclear. To further analyze the association between different alleles at the single nucleotide polymorphism (SNP) rs2237892 within KCNQ1 and TD2M and its complications, we conducted a case-control study in a Chinese Han population. The C allele of rs2237892 variant contributed to susceptibility to T2DM (odds ratio [OR], 1.45; 95% confidence interval [CI], 1.20–1.75). Genotypes CT (OR, 1.97; 95% CI, 1.24–3.15) and CC (OR, 2.49; 95% CI, 1.57–3.95) were associated with an increased risk of T2DM. Multivariate regression analysis was performed with adjustment of age, gender, and body mass index. We found that systolic blood pressure (P = 0.015), prevalence of hypertension (P = 0.037), and risk of macrovascular disease (OR, 2.10; CI, 1.00–4.45) were significantly higher in subjects with the CC genotype than in the combined population with genotype either CT or TT. Therefore, our data support that KCNQ1 is associated with an increased risk for T2DM and might contribute to the higher incidence of hypertension and macrovascular complications in patients with T2DM carrying the risk allele C though it needs further to be confirmed in a larger population.