Adenosine, a metabolic trigger of the exercise pressor reflex in humans
Adenosine, a metabolic trigger of the exercise pressor reflex in humans
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DOI：
10.1161/01.hyp.37.3.917
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发表时间：
2001-03-01
期刊：
影响因子：
8.3
通讯作者：
Biaggioni, I
中科院分区：
文献类型：
--
作者：
Costa, F;Diedrich, A;Biaggioni, I
有大量的证据表明，腺苷激活肌肉传入神经纤维，导致交感神经刺激，但这个问题仍然存在争议。为了进一步验证这一假设，我们采用了局部注射腺苷到肱动脉，同时监测全身肌肉交感神经活动（MSNA）与腓神经显微神经造影术。如果用腋神经节阻滞阻断前臂传入，则由3 mg臂内腺苷引起的MSNA增加（106+/-32%，n=5，P
There is substantial evidence that adenosine activates muscle afferent nerve fibers leading to sympathetic stimulation, but the issue remains controversial. To further test this hypothesis, we used local injections of adenosine into the brachial artery while monitoring systemic muscle sympathetic nerve activity (MSNA) with peroneal microneurography. The increase in MSNA induced by 3 mg intrabrachial adenosine (106+/-32%) was abolished if forearm afferent traffic was interrupted by axillary ganglionic blockade (21+/-19%, n=5, P