A COMPARISON OF SILVER-NITRATE WITH ERYTHROMYCIN FOR PROPHYLAXIS AGAINST OPHTHALMIA NEONATORUM
A COMPARISON OF SILVER-NITRATE WITH ERYTHROMYCIN FOR PROPHYLAXIS AGAINST OPHTHALMIA NEONATORUM
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DOI：
10.1177/000992289203100506
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发表时间：
1992-05-01
影响因子：
1.6
通讯作者：
APT, L
中科院分区：
文献类型：
--
作者：
ZANONI, D;ISENBERG, SJ;APT, L
虽然预防性眼药水治疗眼炎眼炎是强制性的全国性，国家和医院可以自由选择特定的药物。为了比较这两种药物，我们研究了五年内加州大学洛杉矶分校两所教学医院的结膜炎的发病率和特征。其中一种仅使用1%的硝酸银溶液，在34，772例分娩中有50例，频率为0.14%。另一组仅使用0.5%红霉素软膏，在12，652例分娩中有43例，频率为0.34%。在使用红霉素的医院中，结膜炎和衣原体性结膜炎的发生率更高（p <0.001）。虽然没有统计学意义，淋球菌性结膜炎被发现在四个婴儿，所有在医院使用银硝酸盐。由于发现银在降低所有结膜炎病例的总频率方面更有效，特别是衣原体和革兰氏阴性菌引起的病例，因此仍应将该药物视为结膜炎的主要预防药物。
Although prophylactic eyedrops to treat ophthalmia neonatorum is mandated nationwide, states and hospitals are free to choose specific drugs. To compare two of these agents, we studied the incidence and characteristics of ophthalmia neonatorum in two UCLA teaching hospitals over a five-year period. One, which used 1% silver nitrate solution exclusively, had 50 cases in 34,772 births, a frequency of 0.14%. The other used 0.5% erythromycin ointment exclusively and had 43 cases in 12,652 births, a frequency of 0.34%. Ophthalmia neonatorum was more frequent in the hospital using erythromycin (p < 0.001), as was chlamydial conjunctivitis (p < 0.02). Although not statistically significant, gonococcal conjunctivitis was found in four infants, all in the hospital using silver nitrate. Because silver nitrate was found more effective in decreasing the total frequency of all cases of ophthalmia neonatorum, and cases caused by Chlamydia and gram-negative bacteria specifically, this drug still should be considered as a primary prophylactic agent against ophthalmia neonatorum.