Operational strategies to achieve and maintain malaria elimination.
Operational strategies to achieve and maintain malaria elimination.
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DOI：
10.1016/s0140-6736(10)61269-x
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发表时间：
2010-11-06
期刊：
影响因子：
168.9
通讯作者：
Targett, Geoffrey
中科院分区：
文献类型：
--
作者：
Moonen, Bruno;Cohen, Justin M.;Snow, Robert W.;Slutsker, Laurence;Drakeley, Chris;Smith, David L.;Abeyasinghe, Rabindra R.;Henry Rodriguez, Mario;Maharaj, Rajendra;Tanner, Marcel;Targett, Geoffrey
目前的消灭疟疾战略是基于1960年代全球消灭疟疾方案提出的建议。然而，目前许多考虑消灭艾滋病毒的国家具有很高的内在传播潜力，在没有区域运动支持的情况下，不得不应对输入性病例的持续威胁，强调需要重新审查当代消灭艾滋病毒方案所依据的战略。为了消灭疟疾，各项方案需要通过被动和主动的病例检测方法，集中精力查明和消除感染源。这种方法需要对临床病例和无症状感染者进行适当治疗，并结合有针对性的病媒控制。完全排干传染源是不够的，因为它们可能会被输入的疟疾补充。因此，消灭艾滋病还需要在传入感染导致传播之前对其进行识别和治疗，或者更现实地说，采取区域举措，从源头上杜绝输入。
Present elimination strategies are based on recommendations derived during the Global Malaria Eradication Program of the 1960s. However, many countries considering elimination nowadays have high intrinsic transmission potential and, without the support of a regional campaign, have to deal with the constant threat of imported cases of the disease, emphasising the need to revisit the strategies on which contemporary elimination programmes are based. To eliminate malaria, programmes need to concentrate on identification and elimination of foci of infections through both passive and active methods of case detection. This approach needs appropriate treatment of both clinical cases and asymptomatic infections, combined with targeted vector control. Draining of infectious pools entirely will not be sufficient since they could be replenished by imported malaria. Elimination will thus additionally need identification and treatment of incoming infections before they lead to transmission, or, more realistically, embarking on regional initiatives to dry up importation at its source.