Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment
Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment
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使用与抗体片段缀合的自追踪聚合物对肿瘤进行磁共振成像
DOI：
10.1016/j.bmcl.2015.04.072
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Kondo T.
中科院分区：
文献类型：
--
作者：
Yamada H;Hasegawa Y;Suzuki Y;Imai H;Matsuda T;Kimura Y;Toshimitsu A;Aoyama Y;Kondo T.
A13 C富集的磷酸胆碱聚合物（13 C-PMPC）作为一个自我追踪的MR（磁共振）标签与赫赛汀的片段（scFv），抗抗原Her 2的临床抗体缀合。当注射到荷Her 2（+）（胃）和Her 2（-）（胰腺）肿瘤的模型小鼠中时，抗体-标签缀合物13 C-PMPC-scFv选择性地在Her 2（+）肿瘤中积累，具有快速建立/衰减（积累/清除）特征，并且使用1H-13 C双共振（异源相关）技术，Her 2（+）胃肿瘤被清晰地MR成像。
A13C-enriched phosphorylcholine polymer (13C-PMPC) as a self-traceable MR (magnetic resonance) tag was conjugated with a fragment (scFv) of Herceptin, a clinical antibody against antigen Her2. When injected in model mice bearing Her2(+) (gastric) and Her2(−) (pancreatic) tumors, the antibody-tag conjugate13C-PMPC-scFv selectively accumulated in the Her2(+) tumor with a rapid build-up/decay (accumulation/clearance) profile and, with the use of the1H–13C double-resonance (heteronuclear correlation) technique, the Her2(+) gastric tumor was clearly MR imaged.