DISCOVERY OF ANTIDEPRESSANT ACTIVITY BY FORCED SWIMMING TEST MAY DEPEND ON PRE-EXPOSURE OF RATS TO A STRESSFUL SITUATION
DISCOVERY OF ANTIDEPRESSANT ACTIVITY BY FORCED SWIMMING TEST MAY DEPEND ON PRE-EXPOSURE OF RATS TO A STRESSFUL SITUATION
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DOI：
10.1007/bf00442247
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发表时间：
1989-01-01
影响因子：
3.4
通讯作者：
MELI, A
中科院分区：
文献类型：
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作者：
BORSINI, F;LECCI, A;MELI, A
抗抑郁药诱导的抗不动效应已在暴露或未暴露于试验前阶段的动物中使用强迫游泳试验进行了评估。地昔帕明、马普替林、米安丝氨酸（15和30 mg/kg），诺米芬辛（2.5和5毫克/千克），d-苯丙胺（1和2 mg/kg）和蝇蕈醇（1和2 mg/kg），与丙咪嗪不同（15和30 mg/kg）、LY-171555（0.1和0.2 mg/kg）和东莨菪碱（0.5和0.1 mg/kg）没有减少未接受预试验阶段的大鼠的不动时间。另一方面，所有测试的药物都减少了暴露于预测试阶段的大鼠的不动时间。此外，地昔帕明（20 mg/kg）和诺米芬辛（5 mg/kg）的抗行动不便作用程度与动物在预试验时暴露的水（0.4、15和30 cm）水平成比例增加。此外，地昔帕明减少不动时间在大鼠预先暴露于不同类型的压力，从强迫游泳，寒冷，约束或脚休克。所有药物均在试验前24、5和1 h腹腔注射三次。目前的研究结果表明，一个紧张的预测试会议可能会揭示抗抑郁药在强迫游泳试验的药理学特性。这也被以下事实所证实：在游泳预试验前30分钟给予地西泮（2.5和5 mg/kg）拮抗15 mg/kg地昔帕明的抗不动作用。
Antidepressant-induced anti-immobility effects have been assessed in animals exposed or not to a pretest session using the forced swimming test. Desipramine, maprotiline, mianserine (15 and 30 mg/kg), nomifensine (2.5 and 5 mg/kg), d-amphetamine (1 and 2 mg/kg) and muscimol (1 and 2 mg/kg), unlike imipramine (15 and 30 mg/kg), LY-171555 (0.1 and 0.2 mg/kg) and scopolamine (0.5 and 0.1 mg/kg), did not reduce immobility time in rats which had not received the pretest session. On the other hand, all of the drugs tested reduced immobility time in rats exposed to a pretest session. In addition, the degree of antiimobility effects of desipramine (20 mg/kg) and nomifensine (5 mg/kg) increased proportionally with the level of water (0.4, 15 and 30 cm) to which animals were exposed at the time of pretest. Furthermore, desipramine reduced immobility time in rats pre-exposed to types of stress different from forced swimming, cold, restraint or foot-shock. All drugs were injected intraperitoneally three times, 24, 5 and 1 h before testing. The present findings suggest that a stressful pretest session may reveal pharmacological properties of antidepressants in the forced swimming test. This is also substantiated by the fact that diazepam (2.5 and 5 mg/kg) administered 30 min before the swimming pretest antagonized the anti-immobility effect of 15 mg/kg desipramine.