Analysis of cognitive and psychological deficits in systemic lupus erythematosus patients without overt central nervous system disease
Analysis of cognitive and psychological deficits in systemic lupus erythematosus patients without overt central nervous system disease
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DOI：
10.1002/art.1780391213
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发表时间：
1996-12-01
影响因子：
--
通讯作者：
Kotzin, BL
中科院分区：
文献类型：
--
作者：
Kozora, E;Thompson, LL;Kotzin, BL
客观的。旨在检查既往无中枢神经系统疾病（非 CNS SLE）病史的系统性红斑狼疮 (SLE) 患者与抗核糖体 P 蛋白自身抗体相关的认知和心理功能。方法。对 51 名非 CNS SLE 患者、29 名类风湿性关节炎 (RA) 患者和 27 名健康对照者进行了全面的神经心理学和心理测试。 结果。 29% 的非 CNS SLE 患者、31% 的 RA 患者和 11% 的对照组受试者被归类为认知障碍， 与对照组相比，非 CNS SLE 和 RA 患者的智力、注意力和流畅性也有类似的下降。 与 RA 组和对照组相比，非 CNS SLE 患者表现出明显的学习缺陷。 与对照组相比，42% 的非 CNS SLE 患者表现出心理困扰7%的RA患者和6%的对照组，在患者组中，认知功能障碍和心理困扰均与疾病活动性或泼尼松剂量无关，核糖体P蛋白自身抗体血清水平升高与心理或认知异常无关。结论。这些结果表明，非中枢神经系统系统性红斑狼疮患者的某些认知缺陷可能不是系统性红斑狼疮免疫病理学所特有的，相反，学习缺陷以及没有主要精神病理学的心理困扰可能是中枢神经系统狼疮的微妙表现。
Objective. To examine cognitive and psychological functioning in relation to antiribosomal P protein autoantibodies in patients with systemic lupus erythematosus (SLE) who had no previous history of central nervous system disease (non-CNS SLE).Methods. Comprehensive neuropsychological and psychological tests were administered to 51 non-CNS SLE patients, 29 rheumatoid arthritis (RA) patients, and 27 healthy controls.Results. Twenty-nine percent of the non-CNS SLE patients, 31% of the RA patients, and 11% of the control subjects were classified as cognitively impaired, Similar reductions in intelligence, attention, and fluency were detected in the non-CNS SLE and RA patients compared with controls, The non-CNS SLE patients showed a distinct deficit in learning compared with the RA and control groups, Forty-two percent of the non-CNS SLE patients demonstrated psychological distress, compared with 7% of the RA patients and 6% of the controls, In the patient groups, neither cognitive dysfunction nor psychological distress,vas associated with disease activity or prednisone dosage, Elevated serum levels of autoantibodies to ribosomal P protein were not associated with either psychological or cognitive abnormalities.Conclusion. These results suggest that certain cognitive deficits in non-CNS SLE patients may not be specific to the immunopathology of SLE, In contrast, it is possible that deficits in learning, as well as psychological distress without major psychiatric pathology, may be subtle manifestations of CNS lupus.