Giant cell formation in lymphoid tissues of monkeys inoculated with various strains of measles virus.
Giant cell formation in lymphoid tissues of monkeys inoculated with various strains of measles virus.
复制标题
接种各种麻疹病毒株的猴子淋巴组织中巨细胞的形成。
DOI：
--
复制
发表时间：
1970
期刊：
影响因子：
--
通讯作者：
A. Shishido
中科院分区：
文献类型：
--
作者：
K. Yamanouchi;Y. Egashira;N. Uchida;H. Kodama;F. Kobune;M. Hayami;A. Fukuda;A. Shishido
用血清学和组织病理学方法对常规检疫的猕猴自然感染麻疹病毒的过程进行了检测。在血清学估计自然感染时间一周后活检的淋巴结中一致检测到Warthin-Finkeldey型巨细胞，认为是由自然感染引起的。在与自然感染严格隔离的猴子中，对皮下接种各种麻疹病毒株的组织病理学反应进行了比较。由麻疹患者的咽洗液或受感染的猴子组织提取物组成的野生病毒产生大量巨细胞，广泛分布于所有接种猴子的淋巴组织中。相反，减毒疫苗和其他实验室毒株在大多数接种的猴子中不产生巨细胞，只有少数猴子在有限的分布中有少量巨细胞。尽管野生病毒与疫苗或实验室毒株的病理变化有明显差异，但由于几种被认为是未减毒的实验室毒株的表现明显与减毒疫苗相似，因此病理变化与麻疹病毒毒力之间没有明确的相关性。
The course of natural infection with measles virus was examined serologically and histopathologically in monkeys which were kept in routine quarantine. Giant cells of the Warthin-Finkeldey type were consistently detected in the lymph nodes biopsied one week after the serologically estimated time of natural infection, and they were considered to be caused by natural infection. Histopathological responses to subcutaneous inoculations of various strains of measles virus were then compared in monkeys which were kept in strict isolation from natural infection. The wild virus consisting of either throat washings from measles patients or infected monkey tissue extract produced a large number of giant cells widely distributed in the lymphoid tissues of all the monkeys inoculated. On the contrary, attenuated vaccines and other laboratory strains did not produce giant cells in most of the monkeys inoculated except in few monkeys which had small number of giant cells only in a limited distribution. In spite of such a marked difference of pathological changes between the wild virus and the vaccine or laboratory strains, no definite correlation of the pathological changes with the virulence of measles virus could be elucidated since the several laboratory strains which were supposed to be unattenuated behaved apparently in a similar way as the attenuated vaccines .