Geropathology. An inside view of biological aging.
Geropathology. An inside view of biological aging.
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DOI：
10.31491/apt.2022.03.078
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ladiges, Warren
中科院分区：
文献类型：
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作者：
Ladiges, Warren
老年病理学的概念假设所有与年龄相关的损害都是相关的，这使得能够用严重性分数来对器官中的每个损害进行分级，从而产生一个量化值。由于老化的宠物猫与老年人类有相似的年龄相关疾病，因此在衰老过程中发生的组织病理学知识对于确定年龄相关损害如何随着年龄的增长而发展以及与共病的联系将是非常宝贵的。利用特定器官老年病理学的严重程度来预测生物衰老的能力将为在动物模型中研究衰老途径及其在老年相关疾病发展中的作用提供新的途径。
The geropathology concept assumes all age-related lesions are relevant, which allows the ability to grade each lesion in an organ with a severity score resulting in a quantitative value. Because aging pet cats have similar age-related diseases as older humans, knowledge of histopathology occurring during aging would be invaluable to determine how age-related lesions progress with increasing age and the connection with comorbidities. The ability to use the severity of specific organ geropathology to predict biological aging would provide new approaches to study pathways of aging and their role in the development of age-related diseases in animal models.