Possible mechanisms for the loss of goblet cells in mucin-deficient disorders.
Possible mechanisms for the loss of goblet cells in mucin-deficient disorders.
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DOI：
10.1016/s0161-6420(84)34251-8
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发表时间：
1984-06
期刊：
影响因子：
13.7
通讯作者：
Scheffer C. G. Tseng;Lawrence W. Hirst;A. Maumenee;Kenneth R. Kenyon;Tung-Tien Sun;W. Green
中科院分区：
文献类型：
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作者：
Scheffer C. G. Tseng;Lawrence W. Hirst;A. Maumenee;Kenneth R. Kenyon;Tung-Tien Sun;W. Green
通过对人结膜瓣的病理变化和兔结膜转分化的研究，我们确定并关联了杯状细胞丢失的两个病理过程：(1)血管形成的丧失，(2)强烈的炎症。在各种粘蛋白缺乏性疾病的慢性瘢痕阶段，血管的丧失可能与杯状细胞的丢失有关，而在急性炎症阶段，炎症可能是导致杯状细胞缺失的原因。这两个过程之间的确切相互关系仍不清楚。杯状细胞的丢失似乎是鳞状化生的早期征兆，鳞状化生是上皮分化的异常。因此，我们推测血管生成的丧失和强烈的炎症可能对上皮细胞分化有重要影响。
By studying the pathological changes in human conjunctival flaps and the conjunctival transdifferentiation in rabbits, we have identified and correlated two pathological processes with the loss of goblet cells: (1) loss of vascularization, and (2) intense inflammation. Loss of vascularization may be correlated with the loss of goblet cells in the chronic cicatricial stage of various mucin-deficient disorders, whereas inflammation may be responsible for their absence in the acute inflammatory stage. The exact interrelationship between these two processes remains unknown. The loss of goblet cells appears to be an early sign of a spectrum of squamous metaplasia, an abnormality of epithelial differentiation. We therefore speculate that loss of vascularization and intense inflammation may have an important effect on epithelial differentiation.