Soft and Condensed Nanoparticles and Nanoformulations for Cancer Drug Delivery and Repurpose
Soft and Condensed Nanoparticles and Nanoformulations for Cancer Drug Delivery and Repurpose
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DOI：
10.1002/adtp.201900102
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发表时间：
2020-01
影响因子：
4.6
通讯作者：
Wen Yang;Hanitrarimalala Veroniaina;Xiaole Qi;Pengyu Chen;Feng Li;P. Ke
中科院分区：
文献类型：
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作者：
Wen Yang;Hanitrarimalala Veroniaina;Xiaole Qi;Pengyu Chen;Feng Li;P. Ke
药物再利用或重新定位最近被认为是开发癌症治疗药物的高性能策略。这种方法可以显著降低失败的风险，缩短研发时间，并最大限度地减少成本和监管障碍。基于纳米技术的递送系统由于其克服药物递送挑战、增强肿瘤特异性靶向和减少毒副作用的显著能力而在癌症治疗中被广泛研究。随着过去几十年积累的知识不断增加，纳米颗粒制剂和递送为药物的再利用开辟了一条新途径，并在先进的癌症治疗中展示了有希望的结果。在这篇综述中，基于软（即，DNA纳米笼、纳米凝胶和树枝状聚合物）和凝聚的（即，综述了纳米材料（包括贵金属纳米颗粒和金属有机骨架）及其在肿瘤治疗中的应用。
Drug repurpose or reposition has been recently recognized as a high‐performance strategy for developing therapeutic agents for cancer treatment. This approach can significantly reduce the risk of failure, shorten R&D time, and minimize cost and regulatory obstacles. Nanotechnology‐based delivery systems have been extensively investigated in cancer therapy due to their remarkable ability to overcome drug delivery challenges, enhance tumor specific targeting, and reduce toxic side effects. With increasing knowledge accumulated over the past decades, nanoparticle formulation and delivery have opened up a new avenue for repurposing drugs and demonstrated promising results in advanced cancer therapy. In this review, recent developments in nano‐delivery and formulation systems based on soft (i.e., DNA nanocages, nanogels, and dendrimers) and condensed (i.e., noble metal nanoparticles and metal–organic frameworks) nanomaterials, as well as their theranostic applications in drug repurpose against cancer are summarized.