O-171 Exposure to Trichloroacetic Acid via Drinking Water during Pregnancy - Insights from a Nested Biomarker Study
O-171 Exposure to Trichloroacetic Acid via Drinking Water during Pregnancy - Insights from a Nested Biomarker Study
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O-171 怀孕期间通过饮用水接触三氯乙酸 - 嵌套生物标志物研究的见解
DOI：
10.1097/01.ede.0000416828.43877.34
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发表时间：
2012
期刊：
影响因子：
5.4
通讯作者：
Smith R
中科院分区：
文献类型：
--
作者：
Smith R
背景：我们正在调查出生于布拉德福德（BiB）出生队列中妊娠期间的消毒副产品暴露和胎儿生长。以往的流行病学研究往往受到潜在的暴露测量误差和缺乏暴露验证的限制。我们报告的结果从嵌套在BiB cohol.Objectives的生物标志物暴露研究：评估因素驱动暴露于三氯乙酸（TCAA），验证措施的水的使用，并评估一个单一的尿TCAA生物标志物作为衡量暴露在pregnancy.Methods：一个子集的孕妇（n= 39）参加了详细的暴露评估在妊娠28周。测量了妇女尿液和家庭自来水中的TCAA水平，并通过问卷调查和7天日记评估了她们的用水情况。在妊娠35-37周时，重复进行尿TCAA和用水日记测量（n= 14）。结果：女性尿TCAA浓度与家中自来水供应中测量的TCAA之间几乎没有相关性（rho= 0.18，p= 0.29）。然而，尿TCAA与女性在家中饮用冷的未过滤自来水的相关性更强（rho= 0.44，p= 0.007）。对于失业妇女，尿中TCAA与自来水消耗量和TCAA摄入量密切相关，但对于就业妇女，这些相关性较弱。尿TCAA的重复测量只有弱correlated.Conclusions：在这个队列中，TCAA暴露的变异性在很大程度上是由个人自来水消费量。对就业妇女的TCAA暴露评估更为复杂，根据就业状况，在水消费和TCAA摄入量方面可能存在不同的暴露测量误差。
Background: We are investigating disinfection by-product exposure during pregnancy and fetal growth in the Born in Bradford (BiB) birth cohort. Previous epidemiological studies have often been limited by potential exposure measurement error and lack of exposure validation. We report findings from a biomarker exposure study nested within the BiB cohort.Objectives: To evaluate factors driving exposure to trichloroacetic acid (TCAA), validate measures of water-use, and assess a single urinary TCAA biomarker as a measure of exposure during pregnancy.Methods: A subset of pregnant women (n= 39) participated in detailed exposure assessment at 28 weeks gestation. TCAA levels in the women’s urine and home tap water supply were measured, and their water use was assessed by questionnaire and 7-day diary. At 35-37 weeks gestation, repeated urinary TCAA and water-use diary measures were performed (n= 14).Results: There was little correlation between women’s urinary TCAA concentration and TCAA measured in the tap water supply at their homes (rho= 0.18, p= 0.29). However, urinary TCAA was more strongly correlated with women’s consumption of cold unfiltered tap water at home (rho= 0.44, p= 0.007). Urinary TCAA correlated strongly with tap water consumption and TCAA ingestion at home for unemployed women, but for employed women these correlations were weak. Repeated measures of urinary TCAA were only weakly correlated.Conclusions: In this cohort, TCAA exposure variability is largely determined by individual tap water consumption. TCAA exposure assessment is more complex for employed women, with possible differential exposure measurement error in water consumption and TCAA ingestion measures according to employment status.