Effect of heterogeneity and noise on cross frequency phase-phase and phase-amplitude coupling.
Effect of heterogeneity and noise on cross frequency phase-phase and phase-amplitude coupling.
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DOI：
10.3109/0954898x.2014.886781
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Canavier CC
中科院分区：
文献类型：
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作者：
Tikidji-Hamburyan R;Lin EC;Gasparini S;Canavier CC
交叉频率耦合被假设为在神经计算中发挥功能性作用。我们应用相位重置理论的两种类型的交叉频率耦合时，可能会发生一个较慢的振荡器周期性地迫使一个或多个振荡器：相位相位耦合，其中两个振荡锁相，和相位振幅耦合，其中驱动振荡的振幅调制。我们的第一个结果是，相位复位曲线的形状预测的紧密度锁定到一个脉动的强制周期性输入在任何比例的强制固有周期;锁定的紧密度随着比例的增加而降低。得到了非均匀振子群体和单个有噪声振子相位概率密度的理论表达式。使用两种类型的模拟网络和海马CA 1神经元的实验结果得到证实。还得到并证实了低频强迫周期内N个尖峰时间的概率密度的理论表达式。第二个结果是一个建议的相位振幅耦合机制，其中渐进的去磁化导致在低频强迫循环的振幅下降。网络模拟证实了这一机制的理论可行性，它推广到更分散的输入。
Cross-frequency coupling is hypothesized to play a functional role in neural computation. We apply phase resetting theory to two types of cross-frequency coupling that can occur when a slower oscillator periodically forces one or more oscillators: phase-phase coupling, in which the two oscillations are phase-locked, and phase-amplitude coupling, in which the amplitude of the driven oscillation is modulated. Our first result is that the shape of the phase resetting curve predicts the tightness of locking to a pulsatile forcing periodic input at any ratio of forced to intrinsic period; the tightness of the locking decreases as the ratio increases. Theoretical expressions were obtained for the probability density of the phases for a population of heterogeneous oscillators or a noisy single oscillator. Results were confirmed using two types of simulated networks and experiments on hippocampal CA1 neurons. Theoretical expressions were also obtained and confirmed for the probability density of N spike times within a single cycle of low frequency forcing. The second result is a suggested mechanism for phase-amplitude coupling in which progressive desynchronization leads to decreasing amplitude during a low frequency forcing cycle. Network simulations confirmed the theoretical viability of this mechanism, and that it generalizes to more diffuse input.